Accumulating data, including those from large genetic association studies, indicate that
alterations in glutamatergic synapse structure and function represent a common underlying …

Summary Fragile X Syndrome (FXS) is a commonly inherited form of intellectual disability
and one of the leading genetic causes for autism spectrum disorder. Clinical symptoms of …

Technologies that can safely edit genes in the brains of adult animals may revolutionize the
treatment of neurological diseases and the understanding of brain function. Here, we …

Autism spectrum disorder (ASD) is strongly associated with de novo gene mutations. One of
the most commonly affected genes is SCN2A. ASD-associated SCN2A mutations impair the …

Fragile X syndrome (FXS) is the leading inherited cause of autism and intellectual disability.
Aberrant synaptic translation has been implicated in the etiology of FXS, but most lines of …

Animal models provide preclinical tools to investigate the causal role of genetic mutations
and environmental factors in the etiology of autism spectrum disorder (ASD). Knockout and …

More than a hundred de novo single gene mutations and copy‐number variants have been
implicated in autism, each occurring in a small subset of cases. Mutant mouse models with …

Mice and rats emit ultrasonic vocalizations (USVs), which may express their arousal and
emotional states, to communicate with each other. There is continued scientific effort to …

Fragile X syndrome (FXS) is the most common inherited form of autism and intellectual
disability and is caused by the silencing of a single gene, fragile X mental retardation 1 …

De novo and inherited rare genetic disorders (RGDs) are a major cause of human morbidity,
frequently involving neuropsychiatric symptoms. Recent advances in genomic technologies …