Nature is the largest pharmacy in the world. Doxorubicin (DOX) and paclitaxel (PTX) are two
examples of natural-product-derived drugs employed as first-line treatment of various cancer …

Covering: 2011 to 2021 Trifluoromethyl (CF3)-modified natural products have attracted
increasing interest due to their magical effect in binding affinity and/or drug metabolism and …

COVID-19 caused by SARS-CoV-2 has posed a significant threat to global public health
since its outbreak in late 2019. Although there are a few drugs approved for clinical …

Lignans, with various biological activities, such as antitumor, antioxidant, antibacterial, and
antiviral activities, are widely distributed in nature and mainly exist in the xylem of plants. In …

Eleutherococcus senticosus is a medicinal plant widely used in traditional medicine and
edible remedies with effects on anti‐fatigue, sleep improvement, and memory enhancement …

Medicinal plants are the main source of natural metabolites with specialised
pharmacological activities and have been widely examined by plant researchers. Numerous …

Pulmonary fibrosis is an enduring and advancing pulmonary interstitial disease caused by
multiple factors that ultimately lead to structural changes in normal lung tissue. Currently …

Purpose Thymoquinone (TQ), a phytoconstituent of Nigella sativa seeds, has been studied
extensively in various cancer models. However, TQ's limited water solubility restricts its …

Colorectal cancer (CRC) is the third most prevalent human cancer globally. 5-Fluorouracil (5-
FU)-based systemic chemotherapy is the primary strategy for advanced CRC treatment, yet …

Low back pain, primarily caused by intervertebral disc degeneration (IVDD), lacks effective
pharmacological treatments. Oxidative stress has been identified as a significant contributor …