Aortic aneurysms are a common vascular disease in Western populations that can involve
virtually any portion of the aorta. Abdominal aortic aneurysms are much more common than …

Background Aortic aneurysms (AA) are pathological dilations of the aorta, associated with
an overall mortality rate up to 90% in case of rupture. In addition to dilation, the aortic layers …

Aortic aneurysm, including thoracic aortic aneurysm and abdominal aortic aneurysm, is the
second most prevalent aortic disease following atherosclerosis, representing the ninth …

Actin is among the most abundant proteins in eukaryotic cells and assembles into dynamic
filamentous networks regulated by many actin binding proteins. The actin cytoskeleton must …

Reactive oxygen species (ROS) are highly reactive oxygen derivatives. Initially, they were
considered as metabolic by-products (of mitochondria in particular), which consistently lead …

Genetic predisposition and risk factors such as hypertension and smoking can instigate the
development of thoracic aortic aneurysm (TAA), which can lead to highly lethal aortic wall …

Transforming growth factor-β (TGF)-β signaling plays a crucial role in the development and
maintenance of various organs, including the vasculature. Accordingly, the mutations in TGF …

Oxidative stress is a condition determined by an imbalance between antioxidant and
oxidative factors. Oxidative stress can have serious consequences on our organism. Indeed …

Thoracic aortic aneurysm, as occurs in Marfan syndrome, is generally asymptomatic until
dissection or rupture, requiring surgical intervention as the only available treatment. Here …

Peroxynitrous acid/peroxynitrite (ONOOH/ONOO−) is a powerful oxidizing/nitrating system
formed at sites of inflammation, which can modify biological targets, and particularly …