Abstract Development of visceral organs such as the esophagus, lung, liver and stomach
are coordinated by reciprocal signaling interactions between the endoderm and adjacent …

Abstract Trachea-esophageal defects (TEDs), including esophageal atresia (EA),
tracheoesophageal fistula (TEF), and laryngeal-tracheoesophageal clefts (LTEC), are a …

Owing to their manifold roles in health and disease, there have been intense efforts to
synthetically generate blood vessels in vitro from human pluripotent stem cells (hPSCs) …

The endoderm is the cell lineage which gives rise in the embryo to the organs of the
respiratory and gastrointestinal system. In the mouse this may be the germ layer with the …

While the generation of many lineages from pluripotent stem cells has resulted in basic
discoveries and clinical trials, the derivation of tissue-specific mesenchyme via directed …

Mesenchymal cells are necessary for organ development. In the lung, distal tip fibroblasts
contribute to alveolar and airway epithelial cell differentiation and homeostasis. Here, we …

Epigenetics, especially histone marks, functions beyond the DNA sequences to regulate
gene expression. Depletion of NSD1, which catalyzes H3K36me2, leads to both up-and …

Many progresses have recently been achieved in animal somatic cell nuclear transfer
(SCNT). However, embryos derived from SCNT rarely result in live births. Single‐cell RNA …

Millions suffer from incurable lung diseases, and the donor lung shortage hampers organ
transplants. Generating the whole organ in conjunction with the thymus is a significant …

The mesothelium lines body cavities and surrounds internal organs, widely contributing to
homeostasis and regeneration. Mesothelium disruptions cause visceral anomalies and …