Mammalian cells that sustain oncogenic insults can invoke defensive programmes that
either halt their division or trigger their apoptosis, but these countermeasures must be finely …

The INK4a/ARF locus encodes two physically linked tumor suppressor proteins, p16INK4a
and ARF, which regulate the RB and p53 pathways, respectively. The unusual genomic …

Primary lymphomas of the central nervous system (PCNSL) are mainly diffuse large B-cell
lymphomas (DLBCLs) confined to the central nervous system (CNS). Molecular drivers of …

Although the importance of the ARF tumor suppressor in p53 regulation is well established,
numerous studies indicate that ARF also suppresses cell growth in a p53/Mdm2 …

Squamous cell carcinoma of the head and neck (SCCHN) is a common, aggressive,
treatment-resistant cancer with a high recurrence rate and mortality, but the mechanism of …

Abstract The INK4b‐ARF‐INK4a locus encodes two members of the INK4 family of cyclin‐
dependent kinase inhibitors, p15INK4b and p16INK4a, and a completely unrelated protein …

Anti-tumorigenic mechanisms mediated by the tumor suppressor p53, upon oncogenic
stresses, are our bodies' greatest weapons to battle against cancer onset and development …

The mammalian INK4a/ARF locus encodes two linked tumor suppressor proteins, p16INK4a
and ARF, which respectively regulate the retinoblastoma (RB) and p53 pathways. Genetic …

The shared exon 2 of the p14ARF-p16INK4a locus is frequently mutated in human cancers.
However, in contrast to the exon 1β-encoded N-terminal half of ARF, the function of the exon …

Targeting tumour suppressor gene pathways is an attractive therapeutic strategy in cancer.
Since the first clinical trial took place in 1996, at least 20 other trials have investigated the …