Manganese (Mn) is an essential nutrient for intracellular activities; it functions as a cofactor
for a variety of enzymes, including arginase, glutamine synthetase (GS), pyruvate …

Exposure to manganese (Mn) causes clinical signs and symptoms resembling, but not
identical to, Parkinson's disease. Since our last review on this subject in 2004, the past …

Neurodegeneration leads to the loss of structural and functioning components of neurons
over time. Various studies have related neurodegeneration to a number of degenerative …

Manganese (Mn) is an essential heavy metal. However, Mn's nutritional aspects are
paralleled by its role as a neurotoxicant upon excessive exposure. In this review, we …

Neurodegenerative processes encompass a large variety of diseases with different
pathological patterns and clinical presentation such as Amyotrophic Lateral Sclerosis (ALS) …

Although manganese is an essential trace metal, little is known about its transport and
homeostatic regulation. Here we have identified a cohort of patients with a novel autosomal …

The prevalence of metabolic diseases is growing worldwide. Accumulating evidence
suggests that solute carrier (SLC) transporters contribute to the etiology of various metabolic …

SLC39A8 is a membrane transporter responsible for manganese uptake into the cell. Via
whole-exome sequencing, we studied a child that presented with cranial asymmetry, severe …

The aim of this chapter is to summarize key literature findings regarding the role of
micronutrients, mainly vitamins and minerals in health and disease. Various studies have …

Manganese (Mn) is an essential heavy metal that is naturally found in the environment. Daily
intake through dietary sources provides the necessary amount required for several key …