Gastric cancer remains a major unmet clinical problem with over 1 million new cases
worldwide. It is the fourth most commonly occurring cancer in men and the seventh most …

Apoptosis has long been recognized as a mechanism that kills the cancer cells by cytotoxic
drugs. In recent years, studies have proved that pyroptosis can also shrink tumors and inhibit …

Drug resistance developed towards conventional therapy is one of the important reasons for
chemotherapy failure in cancer. The various underlying mechanism for drug resistance …

Chemoresistance remains the major obstacle to achieve optimal prognosis in gastric cancer
patients, and the underlying molecular mechanisms of cancer-associated fibroblasts (CAFs) …

Gastric cancer is an active topic of clinical and basic research due to high morbidity and
mortality. To date, gastrectomy and chemotherapy are the only therapeutic options for gastric …

Multidrug resistance (MDR), defined as the ability of cancer cells to gain resistance to both
conventional and novel chemotherapy agents, is an important barrier in treating …

Chemoresistance is one of the causes of adverse effects in gastric cancer, including a poor
response to cisplatin (DDP). Exosomes loaded with microRNA (miRNA), mRNA, and other …

The efficacy of chemotherapy in cancer therapy is limited due to resistance, treatment
selectivity, and severe adverse effects. Immunotherapy, chemotherapy, targeted therapy …

Gastric cancer (GC) remains one of the most common and malignant types of cancer due to
its rapid progression, distant metastasis, and resistance to conventional chemotherapy …

Background Drug resistance often occurs in the treatment of gastric cancer, which is the
main cause of poor prognosis of chemotherapy. c-Met is overexpressed in a variety of …