Background Multiple studies have confirmed a high prevalence of prognostic germline
mutations in prostate cancer. In recognition, the NCCN guidelines and recommendations for …

Simple Summary This review paper seeks to summarize the current literature on the role of
PARP Inhibitors in Advanced Prostate Cancer in tumors with defects in genes associated …

RAB3B is essential for the transportation and secretion within cells. Its increased expression
is linked to the development and progression of various malignancies. However …

It is paramount important for pathologists and clinicians, who are involved in the
management of prostate cancer (PCa) patients, to understand the role of germline …

Background: Genetic testing, particularly for BRCA1/2, is increasingly important in prostate
cancer (PCa) care, with impact on PCa management and hereditary cancer risk. However …

Background Germline and tumour genetic testing in prostate cancer (PCa) is becoming
more broadly accepted, but testing indications and clinical consequences for carriers in …

DNA–damage repair (DDR) pathways alterations, a growing area of interest in oncology, are
detected in about 20% of patient with prostate cancer and are associated with improved …

Intraductal carcinoma of the prostate (IDC-P), a clinicopathological entity characterized by
malignant prostatic epithelial cells growing within ducts and/or acini, has a distinct …

Background Germline testing has an increasingly important role in prostate cancer care.
However, a relative shortage of genetic counselors necessitates alternate strategies for …

Objective To investigate the inherited mutations and their association with clinical features
and treatment response in young-onset prostate cancer patients. Method Targeted gene …