Prostate cancer plays an undeniably prominent role in public health in our days and health
systems. Its epidemiological impact is quantitatively very close to that of other tumors such …

Integration and further development of genetics-lead medicine in the detection, surveillance
and management of prostate cancer will improve clinical outcomes for men at risk of …

Background: Prostate cancer (PC) is a clinically heterogenous disease, and genetic
mutations may be useful for patient risk stratification. This retrospective cohort study …

As somatic and germline genetic testing continues to play an increasing role in oncology
precision medicine, the need for genetic counseling by informed providers increases. 1 …

Prostate cancer is the most commonly diagnosed non-skin cancer in men. Although early
disease can be cured or remain indolent, advanced castration-resistant disease remains a …

Objectives: We tested the association of germline variants in BRCA1, BRCA2, CHEK2,
CDKN2A, CYP1B1, HOXB13, MLH1, NBS1, NOD2 and PALB2 genes, as well as in 8q24 …

The most important known risk factors for prostate cancer are age, ethnicity, and inherited
genetic variants. The genetic risk factors for adenocarcinoma of the prostate are reviewed …

INTRODUCTION—Prostate cancers are frequently characterized by abnormalities in a
variety of growth factor signaling pathways that control the cell cycle and apoptosis, as well …

Familiäres Prostatakarzinom und genetische Prädisposition Page 1 Der Urologe Leitthema
Urologe 2021 · 60:567–575 https://doi.org/10.1007/s00120-021-01491-y Angenommen: 15 …

Prostate cancer (PCa) is the second most diagnosed cancer type globally and is one of the
leading causes of death in men. Genetic susceptibility plays a significant role in PCa …