The endothelin axis, recognized for its vasoconstrictive action, plays a central role in the
pathology of pulmonary arterial hypertension (PAH). Treatment with approved endothelin …

Heart and kidney interactions are fascinating, in the sense that failure of the one organ
strongly affects the function of the other. In this review paper, we analyze how principal …

Pulmonary arterial hypertension (PH) is a fatal disease marked by excessive pulmonary
vascular cell proliferation. Patients with idiopathic PH express endothelin-1 (ET-1) at high …

The study provides the physicochemical characteristic of bosentan (BOS) in comparison to
tadalafil (TA) and sildenafil citrate (SIL). Despite some reports dealing with thermal …

Background Pulmonary hypertension (PH) is a pathophysiological disorder, which involves
multiple clinical conditions such as the upregulation of the Rho/ROCK signaling pathway …

Aims This study characterized the population pharmacokinetics (PK) of imatinib in patients
with severe pulmonary arterial hypertension (PAH), investigated drug–drug interactions …

Previously, our lab identified transforming growth factor‐alpha (TGFα) as a novel factor
involved in osteoarthritis (OA) in a surgical model of the disease. In the same study, we also …

Resistant hypertension (RH) is the state of uncontrolled blood pressure in the face of
ostensibly optimal pharmacological intervention. It accounts for roughly one in six cases of …

本文综述了儿童肺动脉高压(PAH) 的药物治疗现状, 并简要介绍了新的治疗靶点.
前列环素类似物, 内皮素受体拮抗剂及磷酸二酯酶 5 抑制剂等3 类药物能显著改善PAH …

Tóm tắt Endothelin là một nhóm các peptid nội sinh có vai trò quan trọng trong điều hòa
trương lực mạch máu. Sự tăng biểu hiện quá mức các endothelin có liên quan tới cơ chế …