How many cell types are in the kidney and what do they do?
The kidney maintains electrolyte, water, and acid-base balance, eliminates foreign and
waste compounds, regulates blood pressure, and secretes hormones. There are at least 16 …
waste compounds, regulates blood pressure, and secretes hormones. There are at least 16 …
CLC chloride channels and transporters: structure, function, physiology, and disease
TJ Jentsch, M Pusch - Physiological reviews, 2018 - journals.physiology.org
CLC anion transporters are found in all phyla and form a gene family of eight members in
mammals. Two CLC proteins, each of which completely contains an ion translocation …
mammals. Two CLC proteins, each of which completely contains an ion translocation …
Determinants, maintenance, and function of organellar pH
SA Freeman, S Grinstein… - Physiological reviews, 2023 - journals.physiology.org
The protonation state of soluble and membrane-associated macromolecules dictates their
charge, conformation, and functional activity. In addition, protons (H+ or their equivalents) …
charge, conformation, and functional activity. In addition, protons (H+ or their equivalents) …
Molecular structure and physiological function of chloride channels
TJ Jentsch, V Stein, F Weinreich… - Physiological …, 2002 - journals.physiology.org
Cl− channels reside both in the plasma membrane and in intracellular organelles. Their
functions range from ion homeostasis to cell volume regulation, transepithelial transport, and …
functions range from ion homeostasis to cell volume regulation, transepithelial transport, and …
Distal convoluted tubule
AR Subramanya, DH Ellison - … Journal of the American Society of …, 2014 - journals.lww.com
The distal convoluted tubule is the nephron segment that lies immediately downstream of
the macula densa. Although short in length, the distal convoluted tubule plays a critical role …
the macula densa. Although short in length, the distal convoluted tubule plays a critical role …
Molecular physiology and pathophysiology of electroneutral cation-chloride cotransporters
G Gamba - Physiological reviews, 2005 - journals.physiology.org
Electroneutral cation-Cl− cotransporters compose a family of solute carriers in which cation
(Na+ or K+) movement through the plasma membrane is always accompanied by Cl− in a 1 …
(Na+ or K+) movement through the plasma membrane is always accompanied by Cl− in a 1 …
Genetic kidney diseases
F Hildebrandt - The Lancet, 2010 - thelancet.com
Knowledge of the primary cause of a disease is essential for elucidation of its mechanisms,
and for adequate classification, prognosis, and treatment. Recently, the causes of many …
and for adequate classification, prognosis, and treatment. Recently, the causes of many …
Chloride channels as drug targets
AS Verkman, LJV Galietta - Nature reviews Drug discovery, 2009 - nature.com
Chloride channels represent a relatively under-explored target class for drug discovery as
elucidation of their identity and physiological roles has lagged behind that of many other …
elucidation of their identity and physiological roles has lagged behind that of many other …
Supporting sensory transduction: cochlear fluid homeostasis and the endocochlear potential
P Wangemann - The Journal of physiology, 2006 - Wiley Online Library
The exquisite sensitivity of the cochlea, which mediates the transduction of sound waves into
nerve impulses, depends on the endocochlear potential and requires a highly specialized …
nerve impulses, depends on the endocochlear potential and requires a highly specialized …
Bartter syndrome: causes, diagnosis, and treatment
TS Cunha, IP Heilberg - International journal of nephrology and …, 2018 - Taylor & Francis
Bartter syndrome is an inherited renal tubular disorder caused by a defective salt
reabsorption in the thick ascending limb of loop of Henle, resulting in salt wasting …
reabsorption in the thick ascending limb of loop of Henle, resulting in salt wasting …