The successful treatment of cancer has significantly improved as a result of targeted therapy
and immunotherapy. However, during chemotherapy, cancer cells evolve and can acquire …

Momordica charantia L.(M. charantia), a member of the Cucurbitaceae family, is widely
distributed in tropical and subtropical regions of the world. It has been used in folk medicine …

Abstract Cucurbitacin B (CuB, C 32 H 46 O 8), the most abundant and active member of
cucurbitacins, which are highly oxidized tetracyclic triterpenoids. Cucurbitacins are widely …

Signal transducers and activators of transcription (STATs) comprise a family of cytoplasmic
transcription factors that mediate intracellular signaling that is usually generated at cell …

Cucurbitacins are triterpenoids that confer a bitter taste in cucurbits such as cucumber,
melon, watermelon, squash, and pumpkin. These compounds discourage most pests on the …

Cancer is a prevalent cause of mortality around the world. Aberrated activation of Janus
kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway …

Ethnopharmacological relevance The prevalence of diabetes is on a steady increase
worldwide and it is now identified as one of the main threats to human health in the 21st …

Signal transducers and activators of transcription (STATs) are a family of latent cytoplasmic
transcription factors that transmit signals from the cell membrane to the nucleus. One family …

Ethnopharmacological relevance Medicinal plants of Cucurbitaceae family consist of several
edible fruits and vegetables consumed worldwide since ancient times. The plants of this …

Bitter gourd (Momordica charantia) is a popular cultivated vegetable in Asian and African
countries. To reveal the characteristics of the genomic structure, evolutionary trajectory, and …