Introduction Long term complications of COVID-19, the disease caused by the SARS-CoV-2,
involve many organ systems, dramatically worsening the quality of life, and finally …

Aggregates of misfolded proteins can compromise the function of the 26S proteasome
complex, leaving neurons susceptible to accelerated and impaired protein homeostasis …

Aging-related erectile dysfunction is characterized by a loss of smooth muscle cells (SMCs)
and fibrosis in the corpora cavernosa, and functionally by corporal veno-occlusive …

Abstract Type 5 phosphodiesterase (PDE5) blockade by inhibitors (PDE5i) results in
intracellular cyclic guanosine monophosphate (cGMP) increase and smooth muscle …

(1) Background: Prostacyclin analogues (epoprostenol, treprostinil, and iloprost) induce
vasodilation in pulmonary arterial hypertension (PAH) but also inhibit platelet function.(2) …

Drugs may play an important role in development of thrombosis, and in recent years there
has been increased attention to the importance of this issue. Although drug-induced …

To provide information on the effects of phosphodiesterase type 5 (PDE5) inhibitors on
choroidal vessels and central serous chorioretinopathy (CSC) and possible implications for …

Objective We tested the effect of two phosphodiesterase type-5 (PDE5) inhibitors, sildenafil
and tadalafil, on ophthalmic artery (OA) blood flow velocity and investigated the presence of …

Abstract Sildenafil (SDF), vardenafil (VDF) and tadalafil (TDF) are phosphodiesterase type 5
enzyme inhibitors (PDE5Is), used in the treatment of erectile disorders and to improve …

Objective. The aim of the present study was to evaluate the effects of phosphodiesterase
type 5 (PDE5) inhibitory drugs, sildenafil and tadalafil, in ischemia/reperfusion (I/R)-induced …