Neonatal hypoxia-ischaemia (HI) is the most common cause of death and disability in
human neonates, and is often associated with persistent motor, sensory, and cognitive …

Neonatal hypoxic ischemic encephalopathy (HIE) presents a significant clinical burden with
its high mortality and morbidity rates globally. Therapeutic hypothermia (TH) is now standard …

Intrapartum-related events are the third leading cause of childhood mortality worldwide and
result in one million neurodisabled survivors each year. Infants exposed to a perinatal insult …

Remote ischaemic conditioning (RIC) triggers endogenous protective pathways in distant
organs such as the kidney, heart and brain, and represents an exciting new paradigm in …

Background The endoplasmic reticulum (ER) is responsible for the control of correct protein
folding and protein function which is crucial for cell survival. However, under pathological …

Background and Purpose—Lipoxin A4 (LXA4) has been reported to reduce inflammation in
several neurological injury models. We studied the effects of LXA4 on neuroinflammation …

Novel and innovative approaches are essential in developing new treatments and improving
clinical outcomes in patients with ischemic stroke. Remote ischemic conditioning (RIC) is a …

Background and Purpose—Energy depletion is a critical factor leading to cell death and
brain dysfunction after ischemic stroke. In this study, we investigated whether energy …

Perinatal asphyxia is characterized by oxygen deprivation and lack of perfusion in the
perinatal period, leading to hypoxic-ischemic encephalopathy and sequelae such as …

Cerebral ischemia is a primary cause of human death and long-term disability. Previous
studies have suggested that remote ischemic post-conditioning (RIPC) is a potential useful …