The clustered regularly interspaced short palindromic repeats (CRISPR) renaissance was
catalysed by the discovery that RNA-guided prokaryotic CRISPR-associated (Cas) proteins …

Since 1995, more than 100 transgenic (Tg) mouse models of Alzheimer's disease (AD) have
been generated in which mutant amyloid precursor protein (APP) or APP/presenilin 1 (PS1) …

Background Alzheimer's disease (AD) is an insidious, irreversible, and progressive
neurodegenerative health condition manifesting as cognitive deficits and amyloid beta (Aβ) …

The pathology of familial Alzheimer's disease, which is caused by dominant mutations in the
gene that encodes amyloid-beta precursor protein (APP) and in those that encode presenilin …

Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder
clinically characterized by cognitive impairment, abnormal behavior, and social deficits …

The etiology of many neurological diseases affecting the central nervous system (CNS) is
unknown and still needs more effective and specific therapeutic approaches. Gene therapy …

Zinc, which is the second most abundant trace element in the human central nervous
system, is closely associated with Alzheimer's disease (AD). However, attempts to develop …

Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and Huntington's
disease represent some of the most prevalent neurodegenerative disorders afflicting …

Inflammasomes are multimeric heterogeneous mega-Dalton protein complexes that play key
roles in the host innate immune response to infection and sterile insults. Assembly of the …

CRISPR (clustered regularly interspaced short palindromic Repeats)/Cas9 is a new genetic
editing technology that can be a beneficial method to advance gene therapy. CRISPR …