Schizophrenia is frequently a chronic and disabling disorder, characterized by
heterogeneous positive and negative symptom constellations. The objective of this review …

Despite a lack of recent progress in the treatment of schizophrenia, our understanding of its
genetic and environmental causes has considerably improved, and their relationship to …

The cerebellum, a primary brain structure involved in the control of sensorimotor tasks, also
contributes to higher cognitive functions including reward, emotion and social interaction …

Schizophrenia is a complex and multifactorial disorder generally diagnosed in young adults
at the time of the first psychotic episode of delusions and hallucinations. These positive …

Rats and mice have been demonstrated to show episodic-like memory, a prototype of
episodic memory, as defined by an integrated memory of the experience of an object or …

Almost fifty years after its first introduction into clinical care, clozapine remains the only
evidence-based pharmacological option for treatment-resistant schizophrenia (TRS), which …

Mutations in the synaptic gene SHANK3 lead to a neurodevelopmental disorder known as
Phelan-McDermid syndrome (PMS). PMS is a relatively common monogenic and highly …

Currently available treatments have limited pro-cognitive effects for neuropsychiatric
disorders, such as schizophrenia, Parkinson's disease and Alzheimer's disease. The …

Modern neuropsychopharmacology commenced in the 1950s with the serendipitous
discovery of first-generation antipsychotics and antidepressants which were therapeutically …

Dopamine (DA), as one of the major neurotransmitters in the central nervous system (CNS)
and periphery, exerts its actions through five types of receptors which belong to two major …