Cofactor‐driven cascade reactions enable the efficient preparation of sugar nucleotides

Y Zheng, J Zhang, J Meisner, W Li… - Angewandte Chemie …, 2022 - Wiley Online Library
Glycosylation is catalyzed by glycosyltransferases using sugar nucleotides or occasionally
lipid‐linked phosphosugars as donors. However, only very few common sugar nucleotides …

A “One-Step” Strategy for the Global Characterization of Core-Fucosylated Glycoproteome

Y Wang, R Yuan, B Liang, J Zhang, Q Wen, H Chen… - JACS Au, 2024 - ACS Publications
Core fucosylation, a special type of N-linked glycosylation, is important in tumor proliferation,
invasion, metastatic potential, and therapy resistance. However, the core-fucosylated …

A Sensitive and Reversible Labeling Strategy Enables Global Mapping of the Core‐Fucosylated Glycoproteome on Cell Surfaces

Y Tian, Y Wang, H Yin, Y Luo, F Wei… - Angewandte …, 2022 - Wiley Online Library
Core fucosylation, the attachment of α1, 6‐fucose to the innermost N‐acetylglucosamine
(GlcNAc) residue of N‐glycans, has a strong relationship with tumor growth, invasion …

Sugar nucleotide regeneration system for the synthesis of Bi-and triantennary N-glycans and exploring their activities against siglecs

MT Anwar, SK Kawade, YR Huo, AK Adak… - European Journal of …, 2022 - Elsevier
Enzymatic synthesis that is commenced by the sugar nucleotide regeneration system
(SNRS) protocol can minimize 1) the consumption of exorbitant sugar nucleotides, 2) the …

Systematic Enzymatic Synthesis of dTDP‐Activated Sugar Nucleotides

F Wei, R Yuan, Q Wen, L Wen - … Chemie International Edition, 2023 - Wiley Online Library
Deoxythymidine diphosphate (dTDP)‐activated sugar nucleotides are the most diverse
sugar nucleotides in nature. They serve as the glycosylation donors of glycosyltransferases …

Glyco-Engineering Cell Surfaces by Exo-Enzymatic Installation of GlcNAz and LacNAz Motifs

FV De Leon Gonzalez, ME Boddington… - ACS Chemical …, 2024 - ACS Publications
Exo-enzymatic glyco-engineering of cell-surface glycoconjugates enables the selective
display of well-defined glyco-motifs bearing bioorthogonal functional groups, which can be …

Biocatalytic approaches to building blocks for enzymatic and chemical glycan synthesis

JP Dolan, SC Cosgrove, GJ Miller - JACS Au, 2022 - ACS Publications
While the field of biocatalysis has bloomed over the past 20–30 years, advances in the
understanding and improvement of carbohydrate-active enzymes, in particular, the sugar …

Gram-scale production of sugar nucleotides and their derivatives

S Li, S Wang, Y Wang, J Qu, X Liu, PG Wang… - Green Chemistry, 2021 - pubs.rsc.org
Here, we report a practical sugar nucleotide production strategy that combined a high-
concentrated multi-enzyme catalyzed reaction and a robust chromatography-free selective …

Resin-free peptide synthesis mediated by tri (4-benzoylphenyl) phosphate (TBP) derivatives as small-molecule supports

H Li, J Chao, G Tian, J Hasan, Y Jin… - Organic Chemistry …, 2020 - pubs.rsc.org
In this paper, a series of novel tri (4-benzoylphenyl) phosphate derivatives with unique
precipitation-inducing properties were synthesized and used as C-terminal supports for …

Chemoenzymatic synthesis of homogeneous chondroitin polymers and its derivatives

Y Wang, S Li, X Xu, Y Tan, X Liu, J Fang - Carbohydrate polymers, 2020 - Elsevier
Chondroitin sulfate is a linear glycosaminoglycan widely distributed as an important
extracellular matrix component of mammalian cells. It participates in numerous pathological …