Cardiac function is controlled by the autonomic nervous system (ie, the sympathetic and the
parasympathetic nervous systems), which act via adrenoceptors and muscarinic …

Antiadrenergic treatment is currently an emerging and very promising approach to the
treatment of chronic heart failure. Although the adrenergic nervous system can be …

Left ventricular remodeling is a major cause of progressive heart failure and death after
myocardial infarction. Although neoangiogenesis within the infarcted tissue is an integral …

Objectives: We explored the stimulus for B-type natriuretic peptide (BNP) secretion in the
clinical setting of heart failure (HF). Background: Increasingly, plasma BNP levels are being …

Adult mammalian cardiomyocytes are considered terminally differentiated and incapable of
proliferation. Consequently, acutely injured mammalian hearts do not regenerate, they scar …

We tested the hypothesis that the inflammatory cytokines can regulate fibroblast extracellular
matrix metabolism. Neonatal and adult rat cardiac fibroblasts cultures in vitro were exposed …

Background—The role of the giant protein titin in patients with heart failure is not well
established. We investigated titin expression in patients with end-stage heart failure …

In this study, we hypothesized that bone marrow stem cells (BMSCs) protect ischemic
myocardium through paracrine effects that can be further augmented with preconditioning. In …

Background Beta-blocker therapy may improve cardiac function in patients with idiopathic
dilated cardiomyopathy. We tested the hypothesis that beta-blocker therapy produces …

Angiotensin II (AII) is a major determinant of arterial pressure and volume homeostasis,
mainly because of its vascular action via the AII type 1 receptor (AT1R). AII has also been …