Relation between amiodarone and desethylamiodarone plasma concentrations and electrophysiologic effects, efficacy and toxicity

ML Greenberg, BB Lerman, JR Shipe, DL Kaiser… - Journal of the American …, 1987 - Elsevier
Because the value of monitoring amiodarone plasma concentrations remains undefined, this
study was performed to evaluate its role during the management of patients receiving …

A randomized trial of budiodarone in paroxysmal atrial fibrillation

MD Ezekowitz, R Nagarakanti, A Lubinski… - Journal of interventional …, 2012 - Springer
Objective The aim of this study was to investigate the preliminary safety and efficacy of three
doses of budiodarone in patients with paroxysmal atrial fibrillation. Background …

Evaluation of amiodarone free radical toxicity in rat hepatocytes

RJ Ruch, S Bandyopadhyay, P Somani, JE Klaunig - Toxicology letters, 1991 - Elsevier
The possible roles of free radicals and lipid peroxidation in the mechanism of toxicity of
amiodarone (AD)[2-butyl-3-(3', 5'-diiodo-4'α-diethylaminoethoxybenzoyl) benzofuran] and its …

Amiodarone-induced skin pigmentation and multiple basal-cell carcinomas.

B Monk - Br J Dermatol, 1995 - medicinacomplementar.cebinet.com …
Amiodarone-induced skin pigmentation and multiple basal-cell carcinomas. Basal cell carcinoma
following amiodarone therapy. Amio Page 1 Amiodarona provocando hiperpigmentação da …

[HTML][HTML] Predictors of the risk of falls among elderly with chronic atrial fibrillation

ACS dos Santos, MRC Nobre, A Nussbacher… - Clinics, 2012 - Elsevier
OBJECTIVES: Though elderly persons with chronic atrial fibrillation have more comorbidities
that could limit indications for the chronic use of anticoagulants, few studies have focused on …

Fingerprinting of neurotoxic compounds using a mouse embryonic stem cell dual luminescence reporter assay

M Colaianna, S Ilmjärv, H Peterson, I Kern, S Julien… - Archives of …, 2017 - Springer
Identification of neurotoxic drugs and environmental chemicals is an important challenge.
However, only few tools to address this topic are available. The aim of this study was to …

Endocrine disorders and the cerebellum: from neurodevelopmental injury to late-onset ataxia

M Manto, CS Hampe - Handbook of Clinical Neurology, 2018 - Elsevier
Hormonal disorders are a source of cerebellar ataxia in both children and adults. Normal
development of the cerebellum is critically dependent on thyroid hormone, which crosses …

Adverse reactions to antiarrhythmic drugs during therapy for ventricular arrhythmias

TW Nygaard, TD Sellers, TS Cook, JP DiMarco - Jama, 1986 - jamanetwork.com
We analyzed the incidence of adverse reactions to antiarrhythmic drugs in 123 consecutive
patients with a history of sustained ventricular tachycardia or ventricular fibrillation. Blood …

Clinical aspects of amiodarone pulmonary toxicity

JI Kennedy Jr - Clinics in chest medicine, 1990 - Elsevier
Amiodarone pulmonary toxicity is a major clinical problem limiting the utility of this powerful
therapeutic agent. The clinical manifestations of amiodarone lung toxicity are protean, but …

Hepatotoxicity of cardiovascular and antidiabetic drugs

D Halegoua-De Marzio, VJ Navarro - Drug-induced liver disease, 2013 - Elsevier
With the increasing prevalence of cardiovascular disease and associated disorders globally,
there has been a proliferation of medications for antiplatelet therapy, dyslipidemia, glycemic …