Articular chondrocytes are quiescent, fully differentiated cells responsible for the
homeostasis of adult articular cartilage by maintaining cellular survival functions and the fine …

Methylation is the most common posttranscriptional modification in cellular RNAs, which has
been reported to modulate the alteration of RNA structure for initiating relevant functions …

The purpose of this narrative review is to provide an overview of last year's publications in
the field of genetics, genomics and epigenetics in the osteoarthritis (OA) field. Major themes …

Background Although osteoarthritis (OA) is one of the most prevalent joint disorders,
effective biomarkers to diagnose OA are still unavailable. This study aimed to acquire some …

Osteoarthritis (OA) is a chronic musculoskeletal disease characterised by the destruction of
articular cartilage, synovial inflammation and bone remodelling. Disease aetiology is …

Phenotypic variation in skeletal traits and diseases is the product of genetic and
environmental factors. Epigenetic mechanisms include information‐containing factors, other …

Meniscus tears are common knee injuries and a major osteoarthritis (OA) risk factor.
Knowledge gaps that limit the development of therapies for meniscus injury and …

DNA methylation is one of the most studied epigenetic mechanisms that play a pivotal role in
regulating gene expression. The epigenetic component is strongly involved in aging-bone …

Background Lymphatic dysfunction exists in tumor necrosis factor transgenic (TNF-Tg) mice
and rheumatoid arthritis (RA) patients. While joint-draining TNF-Tg popliteal lymphatic …

PAX8 is a key thyroid transcription factor implicated in thyroid gland differentiation and
function, and PAX8 gene methylation is reported to be sensitive to the periconceptional …