Chronic kidney disease (CKD) is characterized by pathological accumulation of extracellular
matrix (ECM) proteins in renal structures. Tubulointerstitial fibrosis is observed in glomerular …

Cells are exposed to a variety of mechanical cues, including forces from their local
environment and physical properties of the tissue. These mechanical cues regulate a vast …

The EGFR/Erk pathway is triggered by extracellular ligand stimulation, leading to stimulus-
dependent dynamics of pathway activity. Although mechanical properties of the …

The spatiotemporal aspects of early signaling events during interactions between cells and
their environment dictate multiple downstream outcomes. While advances in nanopatterning …

Simple Summary Pancreatic cancer (PC) is a highly aggressive malignant tumor with an
extremely poor prognosis. Early diagnosis and treatment are key to improving the survival …

Hemidesmosomes are structural protein complexes localized at the interface of tissues with
high mechanical demand and shear forces. Beyond tissue anchoring, hemidesmosomes …

The life expectancy of patients with high-grade glioma (HGG) has not improved in decades.
One of the crucial tools to enable future improvement is advanced models that faithfully …

Simple Summary Breast cancer remains the second leading cause of cancer-related deaths
in women, and about 1 in 8 women in the United States develops invasive breast cancer in …

This review examines the concerted role of Epidermal Growth Factor Receptor (EGFR) and
integrins in regulating Reactive oxygen species (ROS) production through different signaling …

Cell surface proteins carrying N-glycans play important roles in inter-and intracellular
processes including cell adhesion, development, and cellular recognition. Dysregulation of …