The absorption of oral drugs is frequently plagued by significant variability with potentially
serious therapeutic consequences. The source of variability can be traced back to …

Although oral drug delivery is the preferred administration route and has been used for
centuries, modern drug discovery and development pipelines challenge conventional …

Accurate in vivo predictions of intestinal absorption of low solubility drugs require knowing
their solubility in physiologically relevant dissolution media. Aspirated human intestinal …

Physiologically‐based pharmacokinetic (PBPK) modeling and simulation provides
mechanism‐based predictions of the pharmacokinetics of an active ingredient following its …

Ingestible sensor systems are unique tools for obtaining physiological data from an
undisturbed gastrointestinal tract. Since their dimensions correspond to monolithic oral …

The purpose of this review is to summarize the current knowledge on three physiological
determinants of oral drug absorption, ie, gastric emptying, volumes and composition of …

This collection of contributions from the European Network on Understanding
Gastrointestinal Absorption-related Processes (UNGAP) community assembly aims to …

The composition of gastrointestinal (GI) fluids is crucial for the dissolution, solubilization, and
absorption of orally administered drugs. Disease-or age-related changes in GI fluid …

Biorelevant dissolution testing has been widely used to better understand a drug or
formulation's behavior in the human gastrointestinal (GI) tract. The successful evaluation of …

The present work aimed to differentiate between in vitro dissolution profiles of ibuprofen as
input for GastroPlus™ and to see the impact on systemic exposure. In vitro dissolution …