Sickle cell disease is a very variable condition, with outcomes ranging from death in
childhood to living relatively symptom free into the 8 th decade. Much of this variability is …

Sickle-cell anaemia is the most common cause of stroke in children, and stroke is one of the
most devastating complications of sickle-cell disease. Overt strokes are typically due to large …

The sickle hemoglobin is an abnormal hemoglobin due to point mutation (GAG→ GTG) in
exon 1 of the β globin gene resulting in the substitution of glutamic acid by valine at position …

Children with sickle cell anemia (HbSS) are at high risk for neurologically overt cerebral
infarcts associated with stroke and neurologically silent cerebral infarcts correlated with …

Children with sickle cell disease (SCD) and strokes receive blood transfusion therapy for
secondary stroke prevention; despite this, approximately 20% experience second overt …

Sickle cell disease (SCD) is one of the most common genetic causes of illness and death in
the world. This is a review of SCD in Africa, which bears the highest burden of disease. The …

The most common form of neurologic injury in sickle cell anemia (SCA) is silent cerebral
infarction (SCI). In the Silent Cerebral Infarct Multi-Center Clinical Trial, we sought to identify …

Sickle cell disease (SCD) predominates in sub‐Saharan Africa, East Mediterranean areas,
Middle East, and India. Nigeria, being the most populous black nation in the world, bears its …

Silent cerebral infarcts (SCIs) are the most commonly recognized cause of neurologic injury
in patients with sickle cell anemia (SCA), identified in $20% of children. In children with SCA …

In 1973, the average life span of a patient with sickle cell disease was 14 years. Thirty years
later, the development of comprehensive care models, day hospitals, and ongoing efforts in …