The valproic acid-induced rodent model of autism

C Nicolini, M Fahnestock - Experimental neurology, 2018 - Elsevier
Autism is a lifelong neurodevelopmental disorder characterized by impairments in social
communication and interaction and by repetitive patterns of behavior, interests and activities …

Reconsidering animal models used to study autism spectrum disorder: Current state and optimizing future

JL Silverman, A Thurm, SB Ethridge… - Genes, brain and …, 2022 - Wiley Online Library
Neurodevelopmental disorders (NDDs), including autism spectrum disorder (ASD) and
intellectual disability (ID), are pervasive, often lifelong disorders, lacking evidence‐based …

Cerebellar modulation of the reward circuitry and social behavior

I Carta, CH Chen, AL Schott, S Dorizan, K Khodakhah - Science, 2019 - science.org
INTRODUCTION Although the cerebellum has long been considered to be a purely motor
structure, recent studies have revealed that it also has critical nonmotor functions. Cerebellar …

Regulation of autism-relevant behaviors by cerebellar–prefrontal cortical circuits

E Kelly, F Meng, H Fujita, F Morgado, Y Kazemi… - Nature …, 2020 - nature.com
Cerebellar dysfunction has been demonstrated in autism spectrum disorders (ASDs);
however, the circuits underlying cerebellar contributions to ASD-relevant behaviors remain …

[HTML][HTML] The Mouse Action Recognition System (MARS) software pipeline for automated analysis of social behaviors in mice

C Segalin, J Williams, T Karigo, M Hui, M Zelikowsky… - Elife, 2021 - elifesciences.org
The study of naturalistic social behavior requires quantification of animals' interactions. This
is generally done through manual annotation—a highly time-consuming and tedious …

[HTML][HTML] Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders

EY Hsiao, SW McBride, S Hsien, G Sharon, ER Hyde… - Cell, 2013 - cell.com
Neurodevelopmental disorders, including autism spectrum disorder (ASD), are defined by
core behavioral impairments; however, subsets of individuals display a spectrum of …

[HTML][HTML] Deep learning-based behavioral analysis reaches human accuracy and is capable of outperforming commercial solutions

O Sturman, L von Ziegler, C Schläppi, F Akyol… - …, 2020 - nature.com
To study brain function, preclinical research heavily relies on animal monitoring and the
subsequent analyses of behavior. Commercial platforms have enabled semi high …

A standardized social preference protocol for measuring social deficits in mouse models of autism

B Rein, K Ma, Z Yan - Nature protocols, 2020 - nature.com
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social
communication deficits and other behavioral abnormalities. The three-chamber social …

The neuroendocrinology of the microbiota-gut-brain axis: a behavioural perspective

S Cussotto, KV Sandhu, TG Dinan, JF Cryan - Frontiers in …, 2018 - Elsevier
The human gut harbours trillions of symbiotic bacteria that play a key role in programming
different aspects of host physiology in health and disease. These intestinal microbes are …

Altered cerebellar connectivity in autism and cerebellar-mediated rescue of autism-related behaviors in mice

CJ Stoodley, AM D'Mello, J Ellegood… - Nature …, 2017 - nature.com
Cerebellar abnormalities, particularly in Right Crus I (RCrusI), are consistently reported in
autism spectrum disorders (ASD). Although RCrusI is functionally connected with ASD …