Computational prediction of potential drug-like compounds from Cannabis sativa leaf extracts targeted towards Alzheimer therapy
This study was aimed at evaluating the inhibitory effects of the phytochemicals from the
Cannabis sativa (Cannabis) leaf extracts against Alzheimer's disease (AD) protein targets …
Cannabis sativa (Cannabis) leaf extracts against Alzheimer's disease (AD) protein targets …
[HTML][HTML] Soyasapogenol-B as a potential multitarget therapeutic agent for neurodegenerative disorders: molecular docking and dynamics study
Neurodegenerative disorders involve various pathophysiological pathways, and finding a
solution for these issues is still an uphill task for the scientific community. In the present …
solution for these issues is still an uphill task for the scientific community. In the present …
[HTML][HTML] Green synthesis of zinc oxide nanoparticles using aqueous extract of shilajit and their anticancer activity against HeLa cells
P Perumal, NA Sathakkathulla, K Kumaran… - Scientific Reports, 2024 - nature.com
In the present study, ZnO nanoparticles have been synthesized using an aqueous extract of
shilajit. The nanoparticles were characterized using different techniques such as UV …
shilajit. The nanoparticles were characterized using different techniques such as UV …
[HTML][HTML] Secondary metabolites from plants possessing inhibitory properties against beta-amyloid aggregation as revealed by thioflavin-T assay and correlations with …
Alzheimer's disease is a neurodegenerative disorder for which there is a continuous search
of drugs able to reduce or stop the cognitive decline. Beta-amyloid peptides are composed …
of drugs able to reduce or stop the cognitive decline. Beta-amyloid peptides are composed …
[HTML][HTML] Pharmacological modulators of tau aggregation and spreading
A Dominguez-Meijide, E Vasili, TF Outeiro - Brain Sciences, 2020 - mdpi.com
Tauopathies are neurodegenerative disorders characterized by the deposition of
aggregates composed of abnormal tau protein in the brain. Additionally, misfolded forms of …
aggregates composed of abnormal tau protein in the brain. Additionally, misfolded forms of …
[HTML][HTML] Discovery of 1-(phenylsulfonyl)-1H-indole-based multifunctional ligands targeting cholinesterases and 5-HT6 receptor with anti-aggregation properties …
T Wichur, A Pasieka, J Godyń, D Panek, I Góral… - European Journal of …, 2021 - Elsevier
Multifunctional ligands as an essential variant of polypharmacology are promising
candidates for the treatment of multi-factorial diseases like Alzheimer's disease. Based on …
candidates for the treatment of multi-factorial diseases like Alzheimer's disease. Based on …
[HTML][HTML] Renal contributions in the pathophysiology and neuropathological substrates shared by chronic kidney disease and Alzheimer's disease
Chronic kidney disease and Alzheimer's disease are chronic conditions highly prevalent in
elderly communities and societies, and a diagnosis of them is devastating and life changing …
elderly communities and societies, and a diagnosis of them is devastating and life changing …
[HTML][HTML] Reappraisal of metabolic dysfunction in neurodegeneration: Focus on mitochondrial function and calcium signaling
The cellular and molecular mechanisms that drive neurodegeneration remain poorly
defined. Recent clinical trial failures, difficult diagnosis, uncertain etiology, and lack of …
defined. Recent clinical trial failures, difficult diagnosis, uncertain etiology, and lack of …
[HTML][HTML] Secondary metabolic profiling, antioxidant potential, enzyme inhibitory activities and in silico and ADME studies: a multifunctional approach to reveal …
Tanacetum falconeri is a significant flowering plant that possesses cytotoxic, insecticidal,
antibacterial, and phytotoxic properties. Its chemodiversity and bioactivities, however, have …
antibacterial, and phytotoxic properties. Its chemodiversity and bioactivities, however, have …
[HTML][HTML] Alzheimer's disease: In silico study of rosemary diterpenes activities
Z Abbaoui, M Merzouki, I Oualdi, A Bitari… - Current Research in …, 2024 - Elsevier
The global surge in Alzheimer's disease poses a significant public health concern. In
response, we study the efficacy of carnosic acid and related abietane-type diterpenes …
response, we study the efficacy of carnosic acid and related abietane-type diterpenes …