The energetics of a fusion pathway is considered, starting from the contact site where two
apposed membranes each locally protrude (as “nipples”) toward each other. The equilibrium …

We studied the mechanism of the lamellar-to-inverted hexagonal (L alpha/H [II]) phase
transition, using time-resolved cryotransmission electron microscopy (TRC-TEM), 31P-NMR …

Anoctamin (ANO)/TMEM16 proteins exhibit diverse functions in cells throughout the body
and are implicated in several human diseases. Although the founding members ANO1 …

Membrane lipids like other amphiphilic molecules can form a variety of different lyotropic
liquid crystallille phases. Among these, the lamellar phase with its muhibilayer structure has …

The ability to repair membrane damage is conserved across eukaryotic cells and is
necessary for the cells to survive a variety of physiological and pathological membrane …

To understand the mechanism of membrane fusion, we have to infer the sequence of
structural transformations that occurs during the process. Here, it is shown how one can …

Morphological plasticity of biological membrane is critical for cellular life, as cells need to
quickly rearrange their membranes. Yet, these rearrangements are constrained in two ways …

Highlights•Tension in cell membrane is produced by actin-membrane interactions, osmotic
and adhesion forces.•As other membrane reshaping processes, membrane fusion depends …

The mechanism of bilayer unification in biological fusion is unclear. We reversibly arrested
hemagglutinin (HA)-mediated cell–cell fusion right before fusion pore opening. A low-pH …

A model of the energetics of lipid assemblies (Siegel. 1993. Biophys. J. 65: 2124–2140) is
used to predict the relative free energy of intermediates in the transitions between lamellar …