Neuronal cell death

M Fricker, AM Tolkovsky, V Borutaite… - Physiological …, 2018 - journals.physiology.org
Neuronal cell death occurs extensively during development and pathology, where it is
especially important because of the limited capacity of adult neurons to proliferate or be …

Arginase: a multifaceted enzyme important in health and disease

RW Caldwell, PC Rodriguez, HA Toque… - Physiological …, 2018 - journals.physiology.org
The arginase enzyme developed in early life forms and was maintained during evolution. As
the last step in the urea cycle, arginase cleaves l-arginine to form urea and l-ornithine. The …

Apoptosis regulation in the penumbra after ischemic stroke: expression of pro-and antiapoptotic proteins

AB Uzdensky - Apoptosis, 2019 - Springer
Ischemic stroke is the leading cause of human disability and mortality in the world. The main
problem in stroke therapy is the search of efficient neuroprotector capable to rescue neurons …

Mechanisms of acupuncture in the regulation of oxidative stress in treating ischemic stroke

XT Su, L Wang, SM Ma, Y Cao, NN Yang… - Oxidative medicine …, 2020 - Wiley Online Library
Ischemic stroke is the major type of cerebrovascular disease usually resulting in death or
disability among the aging population globally. Oxidative stress has been closely linked with …

[HTML][HTML] Oxidative stress in ischemia/reperfusion injuries following acute ischemic stroke

A Jurcau, AI Ardelean - Biomedicines, 2022 - mdpi.com
Recanalization therapy is increasingly used in the treatment of acute ischemic stroke.
However, in about one third of these patients, recanalization is followed by …

Arginase: an old enzyme with new tricks

RB Caldwell, HA Toque, SP Narayanan… - Trends in …, 2015 - cell.com
Arginase has roots in early life-forms. It converts L-arginine to urea and ornithine. The former
provides protection against NH 3; the latter serves to stimulate cell growth and other …

[HTML][HTML] Anti-inflammatory targets for the treatment of reperfusion injury in stroke

A Mizuma, MA Yenari - Frontiers in neurology, 2017 - frontiersin.org
While the mainstay of acute stroke treatment includes revascularization via recombinant
tissue plasminogen activator or mechanical thrombectomy, only a minority of stroke patients …

Estrogens as neuroprotectants: estrogenic actions in the context of cognitive aging and brain injury

EB Engler-Chiurazzi, CM Brown, JM Povroznik… - Progress in …, 2017 - Elsevier
There is ample empirical evidence to support the notion that the biological impacts of
estrogen extend beyond the gonads to other bodily systems, including the brain and …

Role of nitric oxide in neurodegeneration: function, regulation, and inhibition

D Tewari, AN Sah, S Bawari, SF Nabavi… - Current …, 2021 - ingentaconnect.com
Reactive nitrogen species (RNS) and reactive oxygen species (ROS), collectively known as
reactive oxygen and nitrogen species (RONS), are the products of normal cellular …

Second Near‐Infrared (NIR‐II) Window for Imaging‐Navigated Modulation of Brain Structure and Function

K Zhang, FR Chen, L Wang, J Hu - Small, 2023 - Wiley Online Library
For a long time, optical imaging of the deep brain with high resolution has been a challenge.
Recently, with the advance in second near‐infrared (NIR‐II) bioimaging techniques and …