Mesenchymal stem cell-derived exosomes: applications in regenerative medicine

MD Hade, CN Suire, Z Suo - Cells, 2021 - mdpi.com
Exosomes are a type of extracellular vesicles, produced within multivesicular bodies, that
are then released into the extracellular space through a merging of the multivesicular body …

The application of mesenchymal stromal cells (MSCs) and their derivative exosome in skin wound healing: a comprehensive review

D Bian, Y Wu, G Song, R Azizi, A Zamani - Stem Cell Research & Therapy, 2022 - Springer
Recently, mesenchymal stromal cells (MSCs) and also their exosome has become a game-
changing tool in the context of tissue engineering and regenerative medicine. MSCs due to …

Advances in exosome-based drug delivery and tumor targeting: from tissue distribution to intracellular fate

J Shao, J Zaro, Y Shen - International journal of nanomedicine, 2020 - Taylor & Francis
Exosomes or small extracellular vesicles are considered a new generation of bioinspired-
nanoscale drug delivery system (DDS). Endogenous exosomes function as signalosomes …

Differential therapeutic effect of extracellular vesicles derived by bone marrow and adipose mesenchymal stem cells on wound healing of diabetic ulcers and …

M Pomatto, C Gai, F Negro, M Cedrino… - International journal of …, 2021 - mdpi.com
Extracellular vesicles (EVs) derived from mesenchymal stem cells isolated from both bone
marrow (BMSCs) and adipose tissue (ADSCs) show potential therapeutic effects. These …

Mesenchymal stem/stromal cell-derived exosomes in regenerative medicine and cancer; overview of development, challenges, and opportunities

A Hassanzadeh, HS Rahman, A Markov… - Stem cell research & …, 2021 - Springer
Recently, mesenchymal stem/stromal cells (MSCs) and their widespread biomedical
applications have attracted great consideration from the scientific community around the …

Extracellular vesicles for tissue repair and regeneration: Evidence, challenges and opportunities

A Nagelkerke, M Ojansivu, L van der Koog… - Advanced drug delivery …, 2021 - Elsevier
Extracellular vesicles (EVs) are biological nanoparticles naturally secreted by cells, acting
as delivery vehicles for molecular messages. During the last decade, EVs have been …

The tissue origin effect of extracellular vesicles on cartilage and bone regeneration

Q Li, H Yu, M Sun, P Yang, X Hu, Y Ao, J Cheng - Acta Biomaterialia, 2021 - Elsevier
Direct implantation of mesenchymal stem cells (MSCs) for cartilage and bone tissue
engineering faces challenges, such as immune rejection and loss of cellular viability or …

Comprehensive proteomic analysis of exosomes derived from human bone marrow, adipose tissue, and umbilical cord mesenchymal stem cells

Z Wang, Z He, S Liang, Q Yang, P Cheng… - Stem Cell Research & …, 2020 - Springer
Background Mesenchymal stem cell (MSC)-derived exosomes have shown comprehensive
application prospects over the years. Despite performing similar functions, exosomes from …

Exosome-loaded hydrogels: a new cell-free therapeutic approach for skin regeneration

B Safari, M Aghazadeh, S Davaran… - European Journal of …, 2022 - Elsevier
The treatment of unhealable and chronic cutaneous wounds is a significant challenge for the
healthcare system. Hence, there has been heightened interest in the development of …

Exosomes as potential functional nanomaterials for tissue engineering

Y Yao, Y Jiang, J Song, R Wang, Z Li… - Advanced …, 2023 - Wiley Online Library
Exosomes are cell‐derived extracellular vesicles of 40–160 nm diameter, which carry
numerous biomolecules and transmit information between cells. They are used as functional …