[HTML][HTML] mTOR as a central regulator of lifespan and aging
The mammalian/mechanistic target of rapamycin (mTOR) is a key component of cellular
metabolism that integrates nutrient sensing with cellular processes that fuel cell growth and …
metabolism that integrates nutrient sensing with cellular processes that fuel cell growth and …
mTOR-mediated regulation of immune responses in cancer and tumor microenvironment
The mechanistic/mammalian target of rapamycin (mTOR) is a downstream mediator in the
phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathways, which plays a pivotal role in …
phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathways, which plays a pivotal role in …
mTORC1 as the main gateway to autophagy
Y Rabanal-Ruiz, EG Otten… - Essays in biochemistry, 2017 - portlandpress.com
Cells and organisms must coordinate their metabolic activity with changes in their
environment to ensure their growth only when conditions are favourable. In order to maintain …
environment to ensure their growth only when conditions are favourable. In order to maintain …
mTORC2: The other mTOR in autophagy regulation
J Ballesteros‐Álvarez, JK Andersen - Aging cell, 2021 - Wiley Online Library
The mechanistic target of rapamycin (mTOR) has gathered significant attention as a
ubiquitously expressed multimeric kinase with key implications for cell growth, proliferation …
ubiquitously expressed multimeric kinase with key implications for cell growth, proliferation …
Regulation of mTORC1 by PI3K signaling
CC Dibble, LC Cantley - Trends in cell biology, 2015 - cell.com
The class I phosphoinositide 3-kinase (PI3K)–mechanistic target of rapamycin (mTOR)
complex 1 (mTORC1) signaling network directs cellular metabolism and growth. Activation …
complex 1 (mTORC1) signaling network directs cellular metabolism and growth. Activation …
Targeting the translation machinery in cancer
Dysregulation of mRNA translation is a frequent feature of neoplasia. Many oncogenes and
tumour suppressors affect the translation machinery, making aberrant translation a …
tumour suppressors affect the translation machinery, making aberrant translation a …
Diverse signaling mechanisms of mTOR complexes: mTORC1 and mTORC2 in forming a formidable relationship
M Jhanwar-Uniyal, JV Wainwright, AL Mohan… - Advances in biological …, 2019 - Elsevier
Activation of Mechanistic target of rapamycin (mTOR) signaling plays a crucial role in
tumorigenesis of numerous malignancies including glioblastoma (GB). The Canonical …
tumorigenesis of numerous malignancies including glioblastoma (GB). The Canonical …
Insulin receptor signaling in normal and insulin-resistant states
J Boucher, A Kleinridders… - Cold Spring Harbor …, 2014 - cshperspectives.cshlp.org
In the wake of the worldwide increase in type-2 diabetes, a major focus of research is
understanding the signaling pathways impacting this disease. Insulin signaling regulates …
understanding the signaling pathways impacting this disease. Insulin signaling regulates …
[HTML][HTML] Molecular neurobiology of mTOR
K Switon, K Kotulska, A Janusz-Kaminska… - Neuroscience, 2017 - Elsevier
Mammalian/mechanistic target of rapamycin (mTOR) is a serine-threonine kinase that
controls several important aspects of mammalian cell function. mTOR activity is modulated …
controls several important aspects of mammalian cell function. mTOR activity is modulated …