Elucidating the Role of Lipids in the Aggregation of Amyloidogenic Proteins
D Kurouski - Accounts of Chemical Research, 2023 - ACS Publications
Conspectus The abrupt aggregation of misfolded proteins is linked to the onset and spread
of amyloidogenic diseases, including diabetes type 2, systemic amyloidosis, and …
of amyloidogenic diseases, including diabetes type 2, systemic amyloidosis, and …
The toxicities of A30P and A53T α-synuclein fibrils can be uniquely altered by the length and saturation of fatty acids in phosphatidylserine
Progressive degeneration of dopaminergic neurons in the midbrain, hypothalamus, and
thalamus is a hallmark of Parkinson's disease (PD). Neuronal death is linked to the abrupt …
thalamus is a hallmark of Parkinson's disease (PD). Neuronal death is linked to the abrupt …
Role of saturation and length of fatty acids of phosphatidylserine in the aggregation of transthyretin
The progressive accumulation of transthyretin (TTR), a small protein that transports
thyroxine, in various organs and tissues is observed upon transthyretin amyloidosis, a …
thyroxine, in various organs and tissues is observed upon transthyretin amyloidosis, a …
The influence of Zwitterionic and anionic phospholipids on protein aggregation
The progressive aggregation of misfolded proteins is the underlying molecular cause of
numerous pathologies including Parkinson's disease and injection and transthyretin …
numerous pathologies including Parkinson's disease and injection and transthyretin …
Phospholipids and Cholesterol Determine Molecular Mechanisms of Cytotoxicity of α-Synuclein Oligomers and Fibrils
K Zhaliazka, A Ali, D Kurouski - ACS Chemical Neuroscience, 2024 - ACS Publications
Progressive loss of dopaminergic (DA) neurons in the substantia nigra pars compacta,
hypothalamus, and thalamus is a hallmark of Parkinson's disease. Neuronal death is linked …
hypothalamus, and thalamus is a hallmark of Parkinson's disease. Neuronal death is linked …
Secondary structure and toxicity of transthyretin fibrils can be altered by unsaturated fatty acids
Transthyretin amyloidosis is a severe pathology characterized by the progressive
accumulation of transthyretin (TTR) in various organs and tissues. This highly conserved …
accumulation of transthyretin (TTR) in various organs and tissues. This highly conserved …
Saturation of fatty acids in phosphatidic acid uniquely alters transthyretin stability changing morphology and toxicity of amyloid fibrils
Transthyretin (TTR) is a small, β-sheet-rich tetrameric protein that transports thyroid hormone
thyroxine and retinol. Phospholipids, including phosphatidic acid (PA), can uniquely alter the …
thyroxine and retinol. Phospholipids, including phosphatidic acid (PA), can uniquely alter the …
Colocalization of β-sheets and carotenoids in Aβ plaques revealed with multimodal spatially resolved vibrational spectroscopy
AP de Oliveira, W Chase, MP Confer… - The Journal of …, 2023 - ACS Publications
The aggregation of amyloid β (Aβ) peptides is at the heart of Alzheimer's disease
development and progression. As a result, amyloid aggregates have been studied …
development and progression. As a result, amyloid aggregates have been studied …
Length and saturation of fatty acids in phosphatidylserine determine the rate of lysozyme aggregation simultaneously altering the structure and toxicity of amyloid …
A Frese, C Goode, K Zhaliazka, AP Holman… - Protein …, 2023 - Wiley Online Library
Abrupt aggregation of misfolded proteins is the underlying molecular cause of numerous
severe pathologies including Alzheimer's and Parkinson's diseases. Protein aggregation …
severe pathologies including Alzheimer's and Parkinson's diseases. Protein aggregation …
Plasmalogens Alter the Aggregation Rate of Transthyretin and Lower Toxicity of Transthyretin Fibrils
Heart tissue can experience a progressive accumulation of transthyretin (TTR), a small four
subunit protein that transports holoretinol binding protein and thyroxine. This severe …
subunit protein that transports holoretinol binding protein and thyroxine. This severe …