Cognitive deficits are a major biomedical challenge—and engagement of the brain in
stimulating tasks improves cognition in aged individuals (;) and rodents, through unknown …

The process of aging is marked by a gradual deterioration in the physiological functions and
functional reserves of various tissues and organs, leading to an increased susceptibility to …

Background: Lower limb ischemia-reperfusion injury (IRI-LL) is a common major
complication of orthopedic surgery, especially in elderly patients. It has previously been …

Progressive age-induced deterioration in the structure and function of the cardiovascular
system involves cardiac hypertrophy, diastolic dysfunction, myocardial fibrosis, arterial …

Abstract Thioredoxin-1 (Trx1) has cardioprotective effects on ischemia/reperfusion (I/R)
injury, although its role in ischemic postconditioning (PostC) in middle-aged mice is not …

摘要背景: 缺血后处理是减轻缺血再灌注损伤的有效方式之一, 近年来被越来越广泛地应用于
临床实践, 但其具体分子机制还有待研究. 目的: 探讨piRNA-005854 在衰老心肌细胞缺氧后处理 …

Figure 1. Metabolomics, heart disease and aging. Elderly subjects with heart disease show
multi-organ impairment with significant metabolic alterations as confirmed by circulating …

Ischemic heart diseases are the leading cause of death among cardiovascular diseases.
Reperfusion of the ischemic myocardium is the only way to treat IHD. However, reperfusion …

BACKGROUND: Ischemic postconditioning is one of the effective ways to reduce ischemia-
reperfusion injury and has been more and more widely used in clinical practice in recent …

The study aims to determine the age-gender distribution of individuals with and without
coronary artery disease (CAD) and to analyze the percentage size of CAD detected in …