The language of chromatin modification in human cancers
The genetic information of human cells is stored in the context of chromatin, which is
subjected to DNA methylation and various histone modifications. Such a 'language'of …
subjected to DNA methylation and various histone modifications. Such a 'language'of …
Regulation, functions and transmission of bivalent chromatin during mammalian development
TA Macrae, J Fothergill-Robinson… - … reviews Molecular cell …, 2023 - nature.com
Cells differentiate and progress through development guided by a dynamic chromatin
landscape that mediates gene expression programmes. During development, mammalian …
landscape that mediates gene expression programmes. During development, mammalian …
H3K4me3 regulates RNA polymerase II promoter-proximal pause-release
Trimethylation of histone H3 lysine 4 (H3K4me3) is associated with transcriptional start sites
and has been proposed to regulate transcription initiation,. However, redundant functions of …
and has been proposed to regulate transcription initiation,. However, redundant functions of …
EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis
Canonically, EZH2 serves as the catalytic subunit of PRC2, which mediates H3K27me3
deposition and transcriptional repression. Here, we report that in acute leukaemias, EZH2 …
deposition and transcriptional repression. Here, we report that in acute leukaemias, EZH2 …
Writing, erasing and reading histone lysine methylations
K Hyun, J Jeon, K Park, J Kim - Experimental & molecular medicine, 2017 - nature.com
Histone modifications are key epigenetic regulatory features that have important roles in
many cellular events. Lysine methylations mark various sites on the tail and globular …
many cellular events. Lysine methylations mark various sites on the tail and globular …
2-Oxoglutarate-dependent dioxygenases in cancer
JA Losman, P Koivunen, WG Kaelin Jr - Nature Reviews Cancer, 2020 - nature.com
Oxoglutarate-dependent dioxygenases (2OGDDs) are a superfamily of enzymes that play
diverse roles in many biological processes, including regulation of hypoxia-inducible factor …
diverse roles in many biological processes, including regulation of hypoxia-inducible factor …
Interplay between chromatin marks in development and disease
SM Janssen, MC Lorincz - Nature Reviews Genetics, 2022 - nature.com
DNA methylation (DNAme) and histone post-translational modifications (PTMs) have
important roles in transcriptional regulation. Although many reports have characterized the …
important roles in transcriptional regulation. Although many reports have characterized the …
Epigenetic modulators, modifiers and mediators in cancer aetiology and progression
This year is the tenth anniversary of the publication in this journal of a model suggesting the
existence of'tumour progenitor genes'. These genes are epigenetically disrupted at the …
existence of'tumour progenitor genes'. These genes are epigenetically disrupted at the …
Functions of bromodomain-containing proteins and their roles in homeostasis and cancer
T Fujisawa, P Filippakopoulos - Nature reviews Molecular cell biology, 2017 - nature.com
Bromodomains (BRDs) are evolutionarily conserved protein–protein interaction modules
that are found in a wide range of proteins with diverse catalytic and scaffolding functions and …
that are found in a wide range of proteins with diverse catalytic and scaffolding functions and …
A fate worse than death: apoptosis as an oncogenic process
Apoptotic cell death is widely considered a positive process that both prevents and treats
cancer. Although undoubtedly having a beneficial role, paradoxically, apoptosis can also …
cancer. Although undoubtedly having a beneficial role, paradoxically, apoptosis can also …