Mucociliary clearance is an important primary innate defense mechanism that protects the
lungs from deleterious effects of inhaled pollutants, allergens, and pathogens. Mucociliary …

Inspired air humidification has been reported to show some benefit in bronchiectatic
patients. We have investigated the possibility that one effect might be to enhance …

Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator
(CFTR) protein, an epithelial chloride channel expressed in the airways, pancreas, testis …

Two hypotheses have been proposed recently that offer different views on the role of airway
surface liquid (ASL) in lung defense. The “compositional” hypothesis predicts that ASL …

▪ Abstract The physical removal of viruses and bacteria on the mucociliary escalator is an
important aspect of the mammalian lung's innate defense mechanism. The volume of airway …

There is controversy over whether abnormalities in the salt concentration or volume of
airway surface liquid (ASL) initiate cystic fibrosis (CF) airway disease. In vivo studies of CF …

The concentration of salt in the thin layer of fluid at the surface of large airways, the airway-
surface liquid (ASL), is believed to be of central importance in airway physiology and in the …

Mucus clearance is an important component of the lung's innate defense against disease,
and the ability of the airways to clear mucus is strongly dependent on the volume of liquid on …

Aquaporins (AQPs) are small, integral membrane proteins that facilitate water transport
across cell membranes in response to osmotic gradients. Water transport across epithelia …

Nucleotides within the airway surface liquid (ASL) regulate airway epithelial ion transport
rates by Ca 2+-and protein kinase C-dependent mechanisms via activation of specific P2Y …