Lung-lining fluid (LLF) is a primary constituent of the pulmonary host defense system. It is
distributed continuously throughout the respiratory tract but is heterogeneous regarding its …

Extracellular ATP regulates several elements of the mucus clearance process important for
pulmonary host defense. However, the mechanisms mediating ATP release onto airway …

Water transport across epithelial and endothelial barriers in bronchopulmonary tissues
occurs during airway hydration, alveolar fluid transport, and submucosal gland secretion …

BACKGROUND: Exercise-induced bronchoconstriction (EIB) is a common cause of
symptoms in a subgroup of asthmatic subjects. The pathobiology that makes this group of …

Update on pathogenesis of cystic fibrosis lung disease : Current Opinion in Pulmonary
Medicine Update on pathogenesis of cystic fibrosis lung disease : Current Opinion in …

Identification of a G protein-coupled receptor activated by UDP-glucose led us to develop a
sensitive and specific assay for UDP-glucose mass and to test whether this sugar nucleotide …

More than 1,300 different mutations in the cystic fibrosis transmembrane conductance
regulator (CFTR) are the cause for cystic fibrosis. CFTR is in charge of proper secretion and …

CLCA proteins were discovered in bovine trachea and named for a calcium-dependent
chloride conductance found in trachea and in other secretory epithelial tissues. At least four …

INS37217 [P1-(uridine 5′)-P4-(2′-deoxycytidine 5′) tetraphosphate, tetrasodium salt] is
a deoxycytidine-uridine dinucleotide with agonist activity at the P2Y2 receptor. In primate …

Aquaporin-1 (AQP1) water channel protein expression is increased by hypertonic stress.
The contribution of changes in protein stability to hypertonic induction of AQP1 have not …