Airway surface liquid (ASL) absorption is initiated by Na+ entry via epithelial Na+ channels
(ENaC), which establishes an osmotic gradient that drives fluid from the luminal to serosal …

Recent data indicate the clinical benefit of nebulized hypertonic saline in cystic fibrosis lung
disease, with a proposed mechanism involving sustained increase in airway surface liquid …

Mechanically induced ATP release from human airway epithelial cells regulates mucociliary
clearance through cell surface nucleotide receptors. Ectoenzymes detected on these cells …

Cystic fibrosis (CF) is caused by alterations in the CF transmembrane conductance regulator
(CFTCR) gene. More than 1400 mutations in the CFTCR gene have been described, but the …

Role of Cells and Mediators in Exercise-Induced Bronchoconstriction - Immunology and Allergy
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Mucociliary clearance is composed of three components (ie, mucin secretion, airway surface
hydration, and ciliary-activity) which function coordinately to clear inhaled microbes and …

In normal airway epithelium, the cystic fibrosis transmembrane conductance regulator
(CFTR) transports Cl-ions to the apical surface of the epithelium paralleled by the flow of …

Vocal folds undergo osmotic challenge by mouth breathing during singing, exercising, and
loud speaking. Just 15 min of obligatory oral breathing, to dry the vocal folds, increases …

Background Voice disorders are a worldwide problem impacting human health, particularly
for occupational voice users. Avoidance of surface dehydration is commonly prescribed as a …

Lipoxin A4 has been described as a major signal for the resolution of inflammation and is
abnormally produced in the lungs of patients with cystic fibrosis (CF). In CF, the loss of …