Mucus clearance is an important component of the lung's innate defense system. A failure of
this system brought on by mucus dehydration is common to both cystic fibrosis (CF) and …

Assessment of mucus velocity variations under different conditions including viscosity
variation and boundary conditions is useful to develop mucosal-based medical treatments …

Chronic obstructive lung disease starting in the first months of life remains the major cause
of morbidity and mortality in patients with cystic fibrosis (CF). The discovery of the cystic …

Proton-gated Na+ channels (ASIC) are new members of the epithelial sodium
channel/degenerin gene family. ASIC3 mRNA has been detected in the homogenate of …

We recently reported the presence of anti–aquaporin 5 (AQP5) immunoglobulin G (IgG) in
patients with primary Sjögren syndrome (SS) with a sensitivity of 0.73 and a specificity of …

Accumulating evidence suggests that in cystic fibrosis (CF) patients, airway fluids are
characterized by decreased antibacterial activity, elevated NaCl concentration, and high …

Purpose Dry-air challenges increase the osmolarity of fluid lining the luminal surface of the
proximal airway. The homeostasis of surface fluid is thought to be essential for voice …

In cystic fibrosis (CF), the airway surface liquid (ASL) is depleted. We previously
demonstrated that lipoxin A4 (LXA 4) can modulate ASL height (ASL h) through actions on …

Abstract Models of cellular and subcellular mechanics are essential in gaining an
understanding of the link between forces applied to a cell and its biological response …

The respiratory tract system is protected against pathogens and contaminants by the
mucociliary clearance phenomenon. Simulating the effects of mucociliary clearance is an …