Osmotic water permeability (P f) was measured in spheroid-shaped human nasal airway
epithelial explants pre-exposed to increasing levels of hyperosmotic stress. The fluid-filled …

Background Nebulised drugs, including osmotic agents and saline, are increasingly used
during noninvasive respiratory support, including nasal high-flow therapy. The authors …

Lung health and normal mucus clearance depend on adequate hydration of airway
surfaces. Because transepithelial osmotic gradients drive water flows, sufficient hydration of …

Salt and fluid absorption is a shared function of many of the body's epithelia, but its use is
highly adapted to the varied physiological roles of epithelia-lined organs. These functions …

RECURRENT INFECTION AND DETERIORATION of lung function are the major causes of
morbidity and mortality in cystic fibrosis. Although the genetic defect in cystic fibrosis …

The solid concentration of pulmonary mucus (wt%) is critical to respiratory health. In patients
with respiratory disease, such as Cystic Fibrosis (CF) and Chronic Obstructive Pulmonary …

Na/K ATPase activity is essential for ion transport across epithelia. FXYD3, a γ subunit of the
Na/K ATPase, is expressed in the airway, but its function remains undetermined. Single-cell …

Cystic fibrosis (CF) is a lethal monogenetic disease characterised by impaired water and ion
transport over epithelia. The lung pathology is fatal and causes death in 95% of CF patients …

A thin layer of airway surface liquid (ASL) lines the entire surface of the lung and is the first
point of contact between the lung and the environment. Surfactants contained within this …

Transport of water and electrolytes in airway epithelia involves chloride‐selective ion
channels, which are controlled either by cytosolic Ca2+ or by cAMP. The contributions of the …