A compendium of mutational cancer driver genes
A fundamental goal in cancer research is to understand the mechanisms of cell
transformation. This is key to developing more efficient cancer detection methods and …
transformation. This is key to developing more efficient cancer detection methods and …
Mechanisms of PTEN loss in cancer: It's all about diversity
V Álvarez-Garcia, Y Tawil, HM Wise… - Seminars in cancer biology, 2019 - Elsevier
PTEN is a phosphatase which metabolises PIP 3, the lipid product of PI 3-Kinase, directly
opposing the activation of the oncogenic PI3K/AKT/mTOR signalling network. Accordingly …
opposing the activation of the oncogenic PI3K/AKT/mTOR signalling network. Accordingly …
PTEN/PTENP1:'Regulating the regulator of RTK-dependent PI3K/Akt signalling', new targets for cancer therapy
N Haddadi, Y Lin, G Travis, AM Simpson, NT Nassif… - Molecular cancer, 2018 - Springer
Regulation of the PI-3 kinase (PI3K)/Akt signalling pathway is essential for maintaining the
integrity of fundamental cellular processes, cell growth, survival, death and metabolism, and …
integrity of fundamental cellular processes, cell growth, survival, death and metabolism, and …
Neddylation of PTEN regulates its nuclear import and promotes tumor development
P Xie, Z Peng, Y Chen, H Li, M Du, Y Tan, X Zhang… - Cell research, 2021 - nature.com
PTEN tumor suppressor opposes the PI3K/Akt signaling pathway in the cytoplasm and
maintains chromosomal integrity in the nucleus. Nucleus–cytoplasm shuttling of PTEN is …
maintains chromosomal integrity in the nucleus. Nucleus–cytoplasm shuttling of PTEN is …
A saturation mutagenesis approach to understanding PTEN lipid phosphatase activity and genotype-phenotype relationships
TL Mighell, S Evans-Dutson, BJ O'Roak - The American Journal of Human …, 2018 - cell.com
Phosphatase and tensin homolog (PTEN) is a tumor suppressor frequently mutated in
diverse cancers. Germline PTEN mutations are also associated with a range of clinical …
diverse cancers. Germline PTEN mutations are also associated with a range of clinical …
Gene‐specific criteria for PTEN variant curation: Recommendations from the ClinGen PTEN Expert Panel
Abstract The ClinGen PTEN Expert Panel was organized by the ClinGen Hereditary Cancer
Clinical Domain Working Group to assemble clinicians, researchers, and molecular …
Clinical Domain Working Group to assemble clinicians, researchers, and molecular …
PTEN as a prognostic/predictive biomarker in cancer: an unfulfilled promise?
C Bazzichetto, F Conciatori, M Pallocca, I Falcone… - Cancers, 2019 - mdpi.com
Identifying putative biomarkers of clinical outcomes in cancer is crucial for successful
enrichment, and for the selection of patients who are the most likely to benefit from a specific …
enrichment, and for the selection of patients who are the most likely to benefit from a specific …
Liquid biopsy: creating opportunities in brain space
In recent years, liquid biopsy has emerged as an alternative method to diagnose and
monitor tumors. Compared to classical tissue biopsy procedures, liquid biopsy facilitates the …
monitor tumors. Compared to classical tissue biopsy procedures, liquid biopsy facilitates the …
'Slicing'glioblastoma drivers with the Swiss cheese model
The Swiss cheese model is used to assess risks and explain accidents in a variety of
industries. This model can be applied to dissect the homeostatic mechanisms whose …
industries. This model can be applied to dissect the homeostatic mechanisms whose …
[HTML][HTML] MiR-183-5p is required for non-small cell lung cancer progression by repressing PTEN
Lung cancer is the leading cause in all cancer deaths. A low survival rate and high
recurrence rate of lung cancer make the endeavor to identify new, more effective therapies a …
recurrence rate of lung cancer make the endeavor to identify new, more effective therapies a …