The endothelium can evoke relaxations of the underlying vascular smooth muscle, by
releasing vasodilator substances. The best‐characterized endothelium‐derived relaxing …

Endothelial cells control vascular tone by releasing nitric oxide (NO) produced by
endothelial NO synthase. The activity of endothelial NO synthase is modulated by the …

Adipose tissue is a highly heterogeneous endocrine organ. The heterogeneity among
different anatomical depots stems from their intrinsic differences in cellular and physiological …

Elevated hepatic glucose production, impaired insulin secretion, and insulin resistance-
abnormalities of glucose metabolism typically found in subjects with obesity-are major …

Adipose tissue can be considered as a huge gland producing paracrine and endocrine
hormones, the adipo (cyto) kines. There is growing evidence that these adipo (cyto) kines …

Obesity is associated with higher risks of cardiac arrhythmias. Although this may be partly
explained by concurrent cardiometabolic ill-health, growing evidence suggests that …

Many animal studies have shown that oral administration of the nicotinamide adenine
dinucleotide (NAD+) precursor nicotinamide mononucleotide (NMN) prevents the reduction …

Type 2 diabetes is an emerging health challenge all over the world as a result of
urbanization, high prevalence of obesity, sedentary lifestyle and other stress related factors …

Metabolic syndrome (MetS) as a collection of obesity-associated disorders is associated
with inflammation, oxidative stress, pro-thrombotic state, elevated risk of developing …

Aims Adipocyte fatty acid-binding protein (A-FABP) is an adipokine implicating in various
metabolic diseases. Elevated circulating levels of A-FABP correlate positively with poor …