Chemokines, a subfamily of the cell cytokines, are low molecular weight proteins known to
induce chemotaxis in leukocytes in response to inflammatory and pathogenic signals. A …

Tumour cells are subjected to evolutionary selection pressures during progression from
initiation to metastasis. We analysed the clonal evolution of squamous skin carcinomas …

Introduction Because small-cell lung carcinomas (SCLC) are seldom resected, human
materials for study are limited. Thus, genetically engineered mouse models (GEMMs) for …

Although the incidence of small cell lung cancer (SCLC) has declined during the past 30
years, it remains a frustrating disease to research and treat. Numerous attempts to enhance …

Mutations underlie all cancers, and their identification and study are the foundation of cancer
biology. We describe what we believe to be a novel approach to mutagenesis and cancer …

MYC stimulates both metabolism and protein synthesis, but how cells coordinate these
complementary programs is unknown. Previous work reported that, in a subset of small-cell …

Initiating from a single cell, cancer undergoes clonal evolution, leading to a high degree of
intratumor heterogeneity (ITH). The arising genetic heterogeneity between cancer cells is …

Small cell lung cancer (SCLC) is one of the most deadly cancers and currently lacks
effective targeted treatment options. Recent advances in the molecular characterization of …

Cancer is a genetic disease stemming from genetic and epigenetic mutations and is the
second most common cause of death across the globe. Clustered regularly interspaced …

Unassisted metastasis through the lymphatic system is a mechanism of dissemination thus
far ascribed only to cancer cells. Here, we report that Streptococcus pyogenes also hijack …