Interferon-stimulated genes: what do they all do?

JW Schoggins - Annual review of virology, 2019 - annualreviews.org
In the absence of an intact interferon (IFN) response, mammals may be susceptible to lethal
viral infection. IFNs are secreted cytokines that activate a signal transduction cascade …

Believe it or not: how much can we rely on published data on potential drug targets?

F Prinz, T Schlange, K Asadullah - Nature reviews Drug discovery, 2011 - nature.com
Figure 1| Analysis of the reproducibility of published data in 67 inhouse projects. a| This
figure illustrates the distribution of projects within the oncology, women's health and …

A long journey to reproducible results

GJ Lithgow, M Driscoll, P Phillips - Nature, 2017 - nature.com
A long journey to reproducible results | Nature Skip to main content Thank you for visiting
nature.com. You are using a browser version with limited support for CSS. To obtain the best …

[HTML][HTML] Replication cycle and molecular biology of the West Nile virus

MA Brinton - Viruses, 2014 - mdpi.com
West Nile virus (WNV) is a member of the genus Flavivirus in the family Flaviviridae.
Flaviviruses replicate in the cytoplasm of infected cells and modify the host cell environment …

[HTML][HTML] Illustration of SSMD, z score, SSMD*, z* score, and t statistic for hit selection in RNAi high-throughput screens

XD Zhang - SLAS Discovery, 2011 - Elsevier
Hit selection is the ultimate goal in many high-throughput screens. Various analytic methods
are available for this purpose. Some commonly used ones are z score, z* score, strictly …

Use and abuse of RNAi to study mammalian gene function

WG Kaelin Jr - Science, 2012 - science.org
For decades, scientists studying mammalian cells could only marvel at the genetic tools
available to scientists who studied organisms such as yeasts or drosophila. However, many …

Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects

M Lucanic, WT Plummer, E Chen, J Harke… - Nature …, 2017 - nature.com
Limiting the debilitating consequences of ageing is a major medical challenge of our time.
Robust pharmacological interventions that promote healthy ageing across diverse genetic …

Functional genomic analyses of mendelian and sporadic disease identify impaired eIF2α signaling as a generalizable mechanism for dystonia

JE Rittiner, ZF Caffall, R Hernandez-Martinez… - Neuron, 2016 - cell.com
Dystonia is a brain disorder causing involuntary, often painful movements. Apart from a role
for dopamine deficiency in some forms, the cellular mechanisms underlying most dystonias …

RNAi screening reveals requirement for host cell secretory pathway in infection by diverse families of negative-strand RNA viruses

D Panda, A Das, PX Dinh… - Proceedings of the …, 2011 - National Acad Sciences
Negative-strand (NS) RNA viruses comprise many pathogens that cause serious diseases in
humans and animals. Despite their clinical importance, little is known about the host factors …

Targeting host factors to treat West Nile and dengue viral infections

MN Krishnan, MA Garcia-Blanco - Viruses, 2014 - mdpi.com
West Nile (WNV) and Dengue (DENV) viruses are major arboviral human pathogens
belonging to the genus Flavivirus. At the current time, there are no approved prophylactics …