Background: Because HIV viral suppression is essential for optimal outcomes and
prevention efforts, understanding trends and predictors is imperative to inform public health …

Protein− protein interactions (PPIs) represent a significant portion of functionally relevant
biological interactions, and therefore potential therapeutic targets. Small molecules were …

The blood–testis barrier protects developing germ cells by limiting the entry of xenobiotics
into the adluminal compartment. There is strong evidence that the male genital tract can …

Background: HIV-positive persons who use stimulants such as methamphetamine
experience difficulties navigating the HIV care continuum that undermine the benefits of …

The optimization of the 4-methoxy-6-azaindole series of HIV-1 attachment inhibitors (AIs)
that originated with 1 to deliver temsavir (3, BMS-626529) is described. The most beneficial …

Aim: A myristoylated abacavir (ABC) prodrug was synthesized to extend drug half-life and
bioavailability. Methods: Myristoylated ABC (MABC) was made by esterifying myristic acid to …

Despite new antivirals are being approved against SARS-CoV-2 they suffer from significant
constraints and are not indicated for hospitalized patients, who are left with few antiviral …

HIV-1 reverse transcriptase (RT) is a major drug target in the treatment of HIV-1 infection. RT
inhibitors currently in use include non-nucleoside, allosteric RT inhibitors (NNRTIs), which …

Human lysyl-tRNA synthetase (LysRS) was previously shown to be re-localized from its
normal cytoplasmic location in a multi-aminoacyl-tRNA synthetase complex (MSC) to the …

Preventing HIV transmission by the use of a vaginal microbicide is a topic of considerable
interest in the fight against AIDS. Both a potent anti-HIV agent and an efficient formulation …