An update on drugs with therapeutic potential for SARS-CoV-2 (COVID-19) treatment

S Drożdżal, J Rosik, K Lechowicz, F Machaj… - Drug Resistance …, 2021 - Elsevier
The COVID-19 pandemic is one of the greatest threats to human health in the 21st century
with more than 257 million cases and over 5.17 million deaths reported worldwide (as of …

Endothelial dysfunction in COVID-19: a position paper of the ESC Working Group for Atherosclerosis and Vascular Biology, and the ESC Council of Basic …

PC Evans, GE Rainger, JC Mason… - Cardiovascular …, 2020 - academic.oup.com
The COVID-19 pandemic is an unprecedented healthcare emergency causing mortality and
illness across the world. Although primarily affecting the lungs, the SARS-CoV-2 virus also …

The NLRP3 inflammasome and COVID-19: Activation, pathogenesis and therapeutic strategies

N Zhao, B Di, L Xu - Cytokine & growth factor reviews, 2021 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), exhibits a wide spectrum of clinical presentations …

CD147-spike protein interaction in COVID-19: Get the ball rolling with a novel receptor and therapeutic target

T Behl, I Kaur, L Aleya, A Sehgal, S Singh… - Science of the Total …, 2022 - Elsevier
The combat against the Corona virus disease of 2019 (COVID-19), has created a chaos
among the healthcare institutions and researchers, in turn accelerating the dire need to …

[HTML][HTML] High-mobility group box 1 (HMGB1) in COVID-19: extrapolation of dangerous liaisons

HM Al-Kuraishy, AI Al-Gareeb, L Alkazmi… - …, 2022 - Springer
High-mobility group box 1 (HMGB1), a multifunctional nuclear protein, exists mainly within
the nucleus of all mammal eukaryotic cells. It is actively secreted by the necrotic cells as a …

Dissecting lipid metabolism alterations in SARS-CoV-2

I Casari, M Manfredi, P Metharom, M Falasca - Progress in lipid research, 2021 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the COVID-
19 pandemic that has infected over a hundred million people globally. There have been …

[HTML][HTML] Statin use is associated with lower disease severity in COVID-19 infection

WYT Tan, BE Young, DC Lye, DEK Chew, R Dalan - Scientific Reports, 2020 - nature.com
We aim to study the association of hyperlipidemia and statin use with COVID-19 severity. We
analysed a retrospective cohort of 717 patients admitted to a tertiary centre in Singapore for …

[HTML][HTML] An overview on the treatments and prevention against COVID-19

Y Panahi, AM Gorabi, S Talaei, F Beiraghdar… - Virology Journal, 2023 - Springer
Background The coronavirus disease 2019 (COVID-19) caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to plague the world. While …

Statin therapy did not improve the in-hospital outcome of coronavirus disease 2019 (COVID-19) infection

TI Hariyanto, A Kurniawan - … & Metabolic Syndrome: Clinical Research & …, 2020 - Elsevier
Background and aims The coronavirus disease 2019 (COVID-19) number of death cases is
still increasing. One of the comorbidities associated with severe outcome and mortality of …

[HTML][HTML] Drug design and repurposing with DockThor-VS web server focusing on SARS-CoV-2 therapeutic targets and their non-synonym variants

IA Guedes, LSC Costa, KB Dos Santos, ALM Karl… - Scientific Reports, 2021 - nature.com
The COVID-19 caused by the SARS-CoV-2 virus was declared a pandemic disease in
March 2020 by the World Health Organization (WHO). Structure-Based Drug Design …