Pain is a multidimensional experience with sensory-discriminative, affective-motivational,
and cognitive-evaluative components. Pain aversiveness is one principal cause of suffering …

In this review, we discuss the importance of capsaicin to the current understanding of
neuronal modulation of pain and explore the mechanisms of capsaicin-induced pain. We …

Medicine continues to struggle in its approaches to numerous common subjective pain
syndromes that lack objective signs and remain treatment resistant. Foremost among these …

The capsaicin receptor TRPV1 has been widely characterized in the sensory system as a
key component of pain and inflammation. A large amount of evidence shows that TRPV1 is …

Abstract Treatment of pain has always been a major goal in the clinic, as it is related to
several pathological conditions of inflammatory origin and surgical procedures, which are …

The involvement of the reticular formation (RF) in the transmission and modulation of
nociceptive information has been extensively studied. The brainstem RF contains several …

The main aim of this paper was to show the variety of capsaicin's properties. Capsaicin is an
active component of plants of the Capsicum genus, and is known for its pungency …

Objective Isorhamnetin, a derivative of quercetin, exerts antioxidant and anti-inflammatory
effects in different diseases, and we examined its protective effects against diabetes-related …

The legalization of cannabis in some states has intensified interest in the potential for
cannabis and its constituents to lead to novel therapeutics for pain. Our understanding of the …

The rostral ventromedial medulla (RVM) is a bulbospinal nuclei in the descending pain
modulation system, and directly affects spinal nociceptive transmission through …