Objective: To review preclinical and clinical data for oxaliplatin in the current context of
molecularly targeted therapy. Methods of Study Selection: We searched the PubMed and …

Cisplatin is one of the most commonly used anticancer drugs worldwide. It is mainly used in
the treatment of ovarian cancer, but also used in testicular, bladder and lung cancers. The …

A simple method for preparing 5-fluorouracil surface-functionalized selenium nanoparticles
(5FU-SeNPs) with enhanced anticancer activity has been demonstrated in the present study …

Selenium nanoparticles (SeNPs) are a unique type of nano-sized elemental selenium that
have recently found wide application in biomedicine. It has been shown that the properties …

Background The increased incidence of malignancies in patients with chronic renal failure
has been discussed since the mid-70s. On the other hand, the high frequency of chronic …

Platinum agents have been widely used in cancer chemotherapy for a long time. Cisplatin,
carboplatin, oxaliplatin and nedaplatin have a common chemical structure consisting of …

Most drugs are intended to act on molecular targets residing within a specific tissue or cell
type. Therefore, the drug concentration within the target tissue or cells is most relevant to its …

Introduction: Oxaliplatin, a second-generation platinum analog, has evolved as one of the
most important therapeutic agents in colorectal cancer (CRC) treatment. It has had a major …

Background The aim of this study was to evaluate long-term platinum retention in patients
treated with cisplatin and oxaliplatin. Methods 45 patients, treated 8–75 months before …

Besides worthy development in cancer therapy, cancer is still one of the leading causes of
death, worldwide. The future burden of cancer will probably be even larger because people …