Centella asiatica (also known as Centella asiatica (L.) Urb. or Gotu kola) is a traditional
Chinese medicine with extensive medicinal value, which is commonly used in Southeast …

Mitochondria are involved in ATP supply to cells through oxidative phosphorylation
(OXPHOS), synthesis of key molecules and response to oxidative stress, as well as in …

Parkinson's disease affects 5 million people worldwide, but the molecular mechanisms
underlying its pathogenesis are still unclear. Here, we report a genome-wide meta-analysis …

Prions are proteins that acquire alternative conformations that become self-propagating.
Transformation of proteins into prions is generally accompanied by an increase in β-sheet …

The close apposition between endoplasmic reticulum (ER) and mitochondria represents a
key platform, capable to regulate different fundamental cellular pathways. Among these, Ca …

Like any organ, the brain is susceptible to the march of time and a reduction in mitochondrial
biogenesis is a hallmark of the aging process. In the largest investigation of mitochondrial …

In aging and neurodegenerative diseases, loss of distinct type of neurons characterizes
disease-specific pathological and clinical features, and mitochondria play a pivotal role in …

Most mitochondrial proteins possess N-terminal presequences that are required for targeting
and import into the organelle. Upon import, presequences are cleaved off by matrix …

Abstract Background Mesenchymal stem cells (MSCs) have been explored as promising
tools for treatment of several neurological and neurodegenerative diseases. MSCs release …

Glutamate excitotoxicity leads to fragmented mitochondria in neurodegenerative diseases,
mediated by nitric oxide and S-nitrosylation of dynamin-related protein 1, a mitochondrial …