Animal models of addiction and neuropsychiatric disorders and their role in drug discovery: honoring the legacy of Athina Markou
Each of the co-authors worked with Athina Markou, at different stages of our careers and in
different capacities, to develop, optimize, and use animal models of drug addiction and …
different capacities, to develop, optimize, and use animal models of drug addiction and …
Repeated phencyclidine administration alters glutamate release and decreases GABA markers in the prefrontal cortex of rats
N Amitai, R Kuczenski, MM Behrens, A Markou - Neuropharmacology, 2012 - Elsevier
Repeated phencyclidine (PCP) administration induces cognitive disruptions resembling
those seen in schizophrenia. Alterations in glutamate transmission and γ-aminobutyric acid …
those seen in schizophrenia. Alterations in glutamate transmission and γ-aminobutyric acid …
Targeting glutamate homeostasis for potential treatment of nicotine dependence
F Alasmari, SS Al-Rejaie, SD AlSharari, Y Sari - Brain research bulletin, 2016 - Elsevier
Several studies demonstrated that impairment in glutamatergic neurotransmission is linked
to drug dependence and drug-seeking behavior. Increased extracellular glutamate …
to drug dependence and drug-seeking behavior. Increased extracellular glutamate …
Sex differences in nicotine self-administration in rats during progressive unit dose reduction: implications for nicotine regulation policy
P Grebenstein, D Burroughs, Y Zhang… - Pharmacology …, 2013 - Elsevier
Reducing the nicotine content in tobacco products is being considered by the FDA as a
policy to reduce the addictiveness of tobacco products. Understanding individual differences …
policy to reduce the addictiveness of tobacco products. Understanding individual differences …
Chronic nicotine and withdrawal affect glutamatergic but not nicotinic receptor expression in the mesocorticolimbic pathway in a region-specific manner
F Pistillo, F Fasoli, M Moretti, T McClure-Begley… - Pharmacological …, 2016 - Elsevier
Tobacco addiction is a complex form of dependence process that leads high relapse rates in
people seeking to stop smoking. Nicotine elicits its primary effects on neuronal nicotinic …
people seeking to stop smoking. Nicotine elicits its primary effects on neuronal nicotinic …
Co-administration of ethanol and nicotine: the enduring alterations in the rewarding properties of nicotine and glutamate activity within the mesocorticolimbic system of …
GA Deehan, SR Hauser, RA Waeiss, CP Knight… - …, 2015 - Springer
Rationale The co-abuse of ethanol (EtOH) and nicotine (NIC) increases the likelihood that
an individual will relapse to drug use while attempting to maintain abstinence. There is …
an individual will relapse to drug use while attempting to maintain abstinence. There is …
Involvement of metabotropic glutamate receptor 5 in brain reward deficits associated with cocaine and nicotine withdrawal and somatic signs of nicotine withdrawal
AK Stoker, B Olivier, A Markou - Psychopharmacology, 2012 - Springer
Rationale The involvement of metabotropic glutamate 5 (mGlu5) receptors has been
suggested in the reinforcing effects of psychostimulants. However, little is known about the …
suggested in the reinforcing effects of psychostimulants. However, little is known about the …
Peri-adolescent alcohol consumption increases sensitivity and dopaminergic response to nicotine during adulthood in female alcohol-preferring (P) rats: alterations to …
RA Waeiss, CP Knight, GB Carvajal, RL Bell… - Behavioural brain …, 2019 - Elsevier
Adolescent alcohol drinking has been linked to increased risk for drug abuse during
adulthood. Nicotine microinjected directly into the posterior ventral tegmental area (pVTA) …
adulthood. Nicotine microinjected directly into the posterior ventral tegmental area (pVTA) …
N-acetylcysteine decreased nicotine reward-like properties and withdrawal in mice
MS Bowers, A Jackson, PP Maldoon, MI Damaj - Psychopharmacology, 2016 - Springer
Rationale N-acetylcysteine can increase extrasynaptic glutamate and reduce nicotine self-
administration in rats and smoking rates in humans. Objectives The aim of this study was to …
administration in rats and smoking rates in humans. Objectives The aim of this study was to …
Attenuation of nicotine taking and seeking in rats by the stoichiometry-selective alpha4beta2 nicotinic acetylcholine receptor positive allosteric modulator NS9283
JJ Maurer, K Sandager-Nielsen, HD Schmidt - Psychopharmacology, 2017 - Springer
Rationale The rewarding and reinforcing effects of nicotine are produced, in large part, by
activation of neuronal α4β2* nicotinic acetylcholine receptors (nAChRs), pentameric protein …
activation of neuronal α4β2* nicotinic acetylcholine receptors (nAChRs), pentameric protein …