Abstract Sirtuin 3 (SIRT3), an NAD+-dependent deacetylase, plays a key role in the
modulation of metabolic reprogramming and regulation of cell death, as well as in shaping …

This review delves into the most recent research on the metabolic adaptability of cancer
cells and examines how their metabolic functions can impact their progression into …

Malignant melanoma claims more lives than any other skin malignancy. While primary
melanomas are usually cured via surgical excision, the metastatic form of the disease …

Background anti-Programmed Death-1 (anti-PD-1) immunotherapy has shown promising
manifestation in improving the survival rate of patients with advanced melanoma, with its …

Skin cancer is one of the most prevalent cancers in the Caucasian population. In the United
States, it is estimated that at least one in five people will develop skin cancer in their lifetime …

Malignant melanoma is widely acknowledged as the most lethal skin malignancy. The
metabolic reprogramming in melanoma leads to alterations in glycolysis and oxidative …

β-Galactosylceramidase (GALC) is a lysosomal enzyme involved in sphingolipid metabolism
by removing β-galactosyl moieties from β-galactosylceramide and β-galactosylsphingosine …

Advanced melanoma is an aggressive form of skin cancer characterized by low survival
rates. Less than 50% of advanced melanoma patients respond to current therapies, and of …

The fact that mitochondria play a crucial part in energy generation has led to the nickname
“powerhouses” of the cell being applied to them. They also play a significant role in many …

Follicular helper T (TFH) cells are essential for inducing germinal center (GC) reactions to
mediate humoral adaptive immunity in tumors; however, the mechanisms underlying TFH …