Statins are a cornerstone in the pharmacological prevention of cardiovascular disease.
Although generally well tolerated, a small subset of patients experience statin-related …

Aim: We evaluated the evidence of pharmacogenetic associations with statins in a
systematic review. Methods: Two separate outcomes were considered of interest …

Statins effectively lower LDL cholesterol levels in large studies and the observed
interindividual response variability may be partially explained by genetic variation. Here we …

Background: In the era of precision medicine, more attention is paid to the search for
predictive markers of treatment efficacy and tolerability. Statins are one of the classes of …

Statins are among the most commonly prescribed medications worldwide. Statin-associated
muscle symptoms (SAMS) represent a frequent statin-related adverse effect associated with …

Objective To comprehensively assess the pharmacogenomic evidence of routinely used
drugs for clinical utility. Methods Between January 2, 2011, and May 31, 2013, we assessed …

What is known and objective Statins form the backbone of lipid‐lowering therapy for the
prevention of cardiovascular disease. However, there is large interindividual variability in …

Ab-independent effector functions of B cells, such as Ag presentation and cytokine
production, have been shown to play an important role in a variety of immune-mediated …

Background The proprotein convertase subtilisin/kexin type 9 (PCSK9) has a key role in the
regulation of plasma low-density lipoprotein (LDL) cholesterol by enhancing the degradation …

Ischaemic stroke is a complex disease with some degree of heritability. This means that
heritability factors, such as genetics, could be risk factors for ischaemic stroke. The era of …