One of the features of primate immunodeficiency viruses (HIVs and SIVs) that distinguishes
them from other retroviruses is the array of" accessory" proteins they encode. Here, we …

The cell surface display of peptides by MHC class I molecules to lymphocytes provides the
host with an important surveillance mechanism to protect against invading pathogens …

HIV-1 Nef and the unrelated mouse leukaemia virus glycosylated Gag (glycoGag) strongly
enhance the infectivity of HIV-1 virions produced in certain cell types in a clathrin-dependent …

Despite long-term antiretroviral therapy (ART), HIV-1 persists within a reservoir of CD4+ T
cells that contribute to viral rebound if treatment is interrupted. Identifying the cellular …

Human cells possess an antiviral activity that inhibits the release of retrovirus particles, and
other enveloped virus particles, and is antagonized by the HIV-1 accessory protein, Vpu …

This review describes the diverse array of pathways and molecular targets that are used by
viruses to elude immune detection and destruction. These include targeting of pathways for …

Summary The tetherin/BST2/CD317 protein blocks the release of HIV-1 and other
enveloped viruses by inducing tethering of nascent particles to infected cell surfaces. The …

The accessory Nef protein of HIV and SIV is essential for viral pathogenesis, yet it is
perplexing in its multitude of molecular functions. In this review we analyse the structure …

Background Cellular miRNAs play an important role in the regulation of gene expression in
eukaryotes. Recently, miRNAs have also been shown to be able to target and inhibit viral …

Type 1 interferon (IFN) inhibits the release of HIV-1 virus particles via poorly defined
mechanisms. Here, we show that IFNα induces retention of viral particles on the surface of …